e-Drug3D
495
TRAZODONE
INN
TRAZODONE
cas 19794-93-5
CLASS
NERVOUS SYSTEM
ANTIDEPRESSANT
ANTI-ANXIETY AGENTS
TRIAZOLOPYRIDINE
INHIBITS NEURONAL REUPTAKE OF SEROTONIN
5-HYDROXYTRYPTAMINE 2A/2C RECEPTOR ANTAGONIST
ALPHA 1-ADRENERGIC RECEPTOR ANTAGONIST
ROUTE (list)
ORAL
ATC code
N06AX05
PK parameters
Tmax 9 HOUR
VD 33.8 LITER (65 KILOGRAM)
Cl 5.4 LITER / HOUR (65 KILOGRAM)
PPB 92 PERCENT
t1/2 10 HOUR
Solubility
FREELY SOLUBLE IN WATER
TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR
5-HYDROXYTRYPTAMINE 2C RECEPTOR
ALPHA 1-ADRENERGIC RECEPTOR
Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4
5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A
Formula:
C19H22ClN5O
Calculated chemical properties:
MW 371.87
NB_atoms 26
XLogP 2.36
PSA 47.829
NB_HD 0
NB_HA 6
fsp3 0.37
Lipinski(0=no;1=yes) 1
NB_atoms 26
XLogP 2.36
PSA 47.829
NB_HD 0
NB_HA 6
fsp3 0.37
Lipinski(0=no;1=yes) 1
FDA
NDA 070491 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070492 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070921 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071112 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071113 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071139 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071140 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018207 (label) INN (TRAZODONE HYDROCHLORIDE) DESYREL (PRAGMA) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 070857 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070858 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070942 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRIALODINE (QUANTUM PHARMICS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071196 (label) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (APOTEX INC) APPROVAL= AP YEAR= 1987
NDA 071258 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 1987
NDA 071523 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 1987
NDA 071524 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 1987
NDA 071514 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (ALVOGEN) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071525 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (PLIVA) APPROVAL= AP YEAR= 1988
NDA 071636 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (ALVOGEN) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072192 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 1989
NDA 072193 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 1989
NDA 072483 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (AIPING PHARM INC) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 072484 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 071405 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (NATCO) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 071406 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (NATCO) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073137 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1993
NDA 074357 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 090514 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 022411 (label) INN (TRAZODONE HYDROCHLORIDE) OLEPTRO (ANGELINI PHARMA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 202180 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2013
NDA 205253 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 206923 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017
NDA 204852 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2020
NDA 211116 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (CROSSMEDIKA SA) APPROVAL= AP YEAR= 2024
NDA 217740 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (GRAVITI PHARMS) APPROVAL= AP YEAR= 2024
NDA 218637 (label) INN (TRAZODONE HYDROCHLORIDE) RALDESY (KAMAT) APPROVAL= AP YEAR= 2024
NDA 218988 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (GRANULES) APPROVAL= AP YEAR= 2024
NDA 070491 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070492 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070921 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071112 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071113 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071139 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071140 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018207 (label) INN (TRAZODONE HYDROCHLORIDE) DESYREL (PRAGMA) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 070857 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070858 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070942 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRIALODINE (QUANTUM PHARMICS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071196 (label) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (APOTEX INC) APPROVAL= AP YEAR= 1987
NDA 071258 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 1987
NDA 071523 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 1987
NDA 071524 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 1987
NDA 071514 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (ALVOGEN) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071525 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (PLIVA) APPROVAL= AP YEAR= 1988
NDA 071636 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (ALVOGEN) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072192 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 1989
NDA 072193 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 1989
NDA 072483 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (AIPING PHARM INC) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 072484 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 071405 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (NATCO) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 071406 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (NATCO) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073137 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1993
NDA 074357 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 090514 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 022411 (label) INN (TRAZODONE HYDROCHLORIDE) OLEPTRO (ANGELINI PHARMA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 202180 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2013
NDA 205253 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 206923 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017
NDA 204852 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2020
NDA 211116 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (CROSSMEDIKA SA) APPROVAL= AP YEAR= 2024
NDA 217740 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (GRAVITI PHARMS) APPROVAL= AP YEAR= 2024
NDA 218637 (label) INN (TRAZODONE HYDROCHLORIDE) RALDESY (KAMAT) APPROVAL= AP YEAR= 2024
NDA 218988 (pdf not found) INN (TRAZODONE HYDROCHLORIDE) TRAZODONE HYDROCHLORIDE (GRANULES) APPROVAL= AP YEAR= 2024