e-Drug3D
494
AMINOGLUTETHIMIDE
DISCONTINUED
INN
AMINOGLUTETHIMIDE
cas 125-84-8
CLASS
ANTINEOPLASTIC
AROMATASE INHIBITORS
INHIBITOR OF ADRENOCORTICAL STEROID SYNTHESIS
ANTICONVULSANT (WITHDRAWN)
SUPPRESSION OF ADRENAL FUNCTION IN SELECTED PATIENTS WITH CUSHING’S SYNDROME
ROUTE (list)
ORAL
ATC code
L02BG01
PK parameters
F 100 PERCENT
Tmax 1.5 HOUR
t1/2 12.5 HOUR
Solubility
VERY SLIGHTLY SOLUBLE IN WATER
TARGET CYTOCHROME P450
PDB
5OH1 (CEREBLON ISOFORM 4 FROM MAGNETOSPIRILLUM GRYPHISWALDENSE IN COMPLEX WITH AMINOGLUTETHIMIDE)
Ligand code = 9UQ (link to the list of PDB complexes)
Download experimental 3D coordinates of 9UQ with added hydrogens
Aromatase UNIPROT P11511 CYP19A1
Cholesterol side-chain cleavage enzyme, mitochondrial UNIPROT P05108 CYP11A1
Formula:
C13H16N2O2
Calculated chemical properties:
MW 232.28
NB_atoms 17
XLogP 1.35
PSA 71.271
NB_HD 3
NB_HA 4
fsp3 0.38
Lipinski(0=no;1=yes) 1
NB_atoms 17
XLogP 1.35
PSA 71.271
NB_HD 3
NB_HA 4
fsp3 0.38
Lipinski(0=no;1=yes) 1
FDA
NDA 018202 (pdf not found) INN (AMINOGLUTETHIMIDE) CYTADREN (NOVARTIS) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 018202 (pdf not found) INN (AMINOGLUTETHIMIDE) CYTADREN (NOVARTIS) APPROVAL= AP YEAR= 1980 DISCONTINUED