e-Drug3D
493
AMILORIDE
INN
AMILORIDE
cas 2609-46-3
CLASS
CARDIOVASCULAR
POTASSIUM CONSERVING AGENT
SODIUM CHANNEL BLOCKERS
CYSTIC FIBROSIS
ROUTE (list)
ORAL
ATC code
C03DB01
PK parameters
Tmax 3.5 HOUR
t1/2 7.5 HOUR
TARGET AMILORIDE-SENSITIVE SODIUM CHANNEL
UROKINASE-TYPE PLASMINOGEN ACTIVATOR
UROKINASE-TYPE PLASMINOGEN ACTIVATOR
PDB
4NTX (STRUCTURE OF ACID-SENSING ION CHANNEL IN COMPLEX WITH SNAKE TOXIN AND AMILORIDE)
Ligand code = AMR (link to the list of PDB complexes)
Download experimental 3D coordinates of AMR with added hydrogens
Amiloride-sensitive sodium channel, ENaC UNIPROT P37088 SCNN1A
Formula:
C6H8ClN7O
Calculated chemical properties:
MW 230.65
NB_atoms 15
XLogP -2.90
PSA 135.624
NB_HD 9
NB_HA 7
fsp3 0.00
Lipinski(0=no;1=yes) 0
NB_atoms 15
XLogP -2.90
PSA 135.624
NB_HD 9
NB_HA 7
fsp3 0.00
Lipinski(0=no;1=yes) 0
FDA
NDA 018200 (label) INN (AMILORIDE HYDROCHLORIDE) MIDAMOR (PADAGIS US) APPROVAL= AP YEAR= 1981
NDA 018201 (label) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) MODURETIC 5-50 (MERCK) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 070346 (pdf not found) INN (AMILORIDE HYDROCHLORIDE) AMILORIDE HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 1986
NDA 070347 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) HYDRO-RIDE (PAR PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070795 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (TEVA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071111 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (BARR) APPROVAL= AP YEAR= 1988
NDA 073209 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (RISING) APPROVAL= AP YEAR= 1991
NDA 073334 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073357 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 079133 (pdf not found) INN (AMILORIDE HYDROCHLORIDE) AMILORIDE HYDROCHLORIDE (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2009
NDA 204180 (pdf not found) INN (AMILORIDE HYDROCHLORIDE) AMILORIDE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 018200 (label) INN (AMILORIDE HYDROCHLORIDE) MIDAMOR (PADAGIS US) APPROVAL= AP YEAR= 1981
NDA 018201 (label) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) MODURETIC 5-50 (MERCK) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 070346 (pdf not found) INN (AMILORIDE HYDROCHLORIDE) AMILORIDE HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 1986
NDA 070347 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) HYDRO-RIDE (PAR PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070795 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (TEVA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071111 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (BARR) APPROVAL= AP YEAR= 1988
NDA 073209 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (RISING) APPROVAL= AP YEAR= 1991
NDA 073334 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073357 (pdf not found) INN (AMILORIDE HYDROCHLORIDE ; HYDROCHLOROTHIAZIDE) AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 079133 (pdf not found) INN (AMILORIDE HYDROCHLORIDE) AMILORIDE HYDROCHLORIDE (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2009
NDA 204180 (pdf not found) INN (AMILORIDE HYDROCHLORIDE) AMILORIDE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2015 DISCONTINUED