e-Drug3D

478

cas 14028-44-5

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANT
BLOCKS THE REUPTAKE OF NOREPINEPHRINE AND TO A LESSER EXTENT SEROTONIN INTO THEIR RESPECTIVE NEURONS
BLOCKS THE RESPONSE OF DOPAMINERGIC RECEPTORS TO DOPAMINE
ACTS ON MULTIPLE RECEPTORS AND CHANNELS (PMID24294487)

ROUTE (list)

ORAL

PK parameters

Tmax 1.5 HOUR
PPB 90 PERCENT
t1/2 8 HOUR

MW 313.78
NB_atoms 22
XLogP 3.43
PSA 36.418
NB_HD 1
NB_HA 4
fsp3 0.24
Lipinski(0=no;1=yes) 1

FDA
NDA 018021 (pdf not found) INN (AMOXAPINE) ASENDIN (LEDERLE) APPROVAL= AP YEAR= 1980 NEWMOLECULARENTITY DISCONTINUED
NDA 072418 (pdf not found) INN (AMOXAPINE) AMOXAPINE (WATSON PHARMS TEVA) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072419 (pdf not found) INN (AMOXAPINE) AMOXAPINE (WATSON PHARMS TEVA) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072420 (pdf not found) INN (AMOXAPINE) AMOXAPINE (WATSON PHARMS TEVA) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072421 (pdf not found) INN (AMOXAPINE) AMOXAPINE (WATSON PHARMS TEVA) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072878 (pdf not found) INN (AMOXAPINE) AMOXAPINE (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED OBSOLETE
NDA 072879 (pdf not found) INN (AMOXAPINE) AMOXAPINE (CHARTWELL RX) APPROVAL= AP YEAR= 1991
NDA 072943 (pdf not found) INN (AMOXAPINE) AMOXAPINE (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED OBSOLETE
NDA 072944 (pdf not found) INN (AMOXAPINE) AMOXAPINE (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED OBSOLETE
NDA 072688 (pdf not found) INN (AMOXAPINE) AMOXAPINE (WATSON LABS) APPROVAL= AP YEAR= 1992 OBSOLETE
NDA 072689 (pdf not found) INN (AMOXAPINE) AMOXAPINE (WATSON LABS) APPROVAL= AP YEAR= 1992 OBSOLETE
NDA 072690 (pdf not found) INN (AMOXAPINE) AMOXAPINE (WATSON LABS) APPROVAL= AP YEAR= 1992 OBSOLETE
NDA 072691 (pdf not found) INN (AMOXAPINE) AMOXAPINE (WATSON LABS) APPROVAL= AP YEAR= 1992