e-Drug3D

473

cas 10540-29-1

CLASS

ANTINEOPLASTIC
ESTROGEN ANTAGONIST
BONE DENSITY CONSERVATION AGENTS
OMPETES WITH ESTRADIOL FOR ESTROGEN RECEPTOR

ROUTE (list)

ORAL

PK parameters

Tmax 5 HOUR
PPB 99 PERCENT
t1/2 144 HOUR

TARGET ESTROGEN RECEPTOR

PDB
1YA4 (CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE 1 IN COMPLEX WITH TAMOXIFEN)

Ligand code = CTX (link to the list of PDB complexes)

Download experimental 3D coordinates of CTX with added hydrogens

MW 371.50
NB_atoms 28
XLogP 6.00
PSA 16.582
NB_HD 0
NB_HA 2
fsp3 0.23
Lipinski(0=no;1=yes) 0

FDA
NDA 017970 (label) INN (TAMOXIFEN CITRATE) NOLVADEX (ASTRAZENECA) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 070929 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2003
NDA 074504 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (TEVA) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 074539 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (PHARMACHEMIE) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 074732 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (MYLAN) APPROVAL= AP YEAR= 2003
NDA 074858 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (MAYNE PHARMA) APPROVAL= AP YEAR= 2003 OBSOLETE
NDA 075740 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 075797 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2003
NDA 076027 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (ROXANE) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076179 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076398 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (AEGIS PHARMS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021807 (label) INN (TAMOXIFEN CITRATE) SOLTAMOX (MAYNE PHARMA COMMRCL) APPROVAL= AP YEAR= 2005
NDA 090878 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (APOTEX) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 206694 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 213358 (pdf not found) INN (TAMOXIFEN CITRATE) TAMOXIFEN CITRATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2020