e-Drug3D

471

METOPROLOL


INN
METOPROLOL

cas 37350-58-6
CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ANTIARRHYTHMIC
ANTIANGINAL
ADRENERGIC (BETA-1) BLOCKER
SYMPATHOLYTICS

ROUTE (list)

ORAL INJECTION

ATC code

C07AB02
C07FX03
C07FB13
C07FB02
C07FX05
C07CB02
C07BB02
C07BB52

PK parameters

F 50 PERCENT
Tmax 1 HOUR
VD 201.5 LITER (65 KILOGRAM)
Cl 50.7 LITER / HOUR (65 KILOGRAM)
PPB 12 PERCENT
t1/2 5 HOUR

Solubility

VERY SOLUBLE IN WATER


Target

TARGET BETA-1 ADRENERGIC RECEPTOR

DrugCentral

Beta-1 adrenergic receptor UNIPROT P08588 ADRB1

Download SDF file 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

Formula:
C15H25NO3

Calculated chemical properties:

MW 267.36
NB_atoms 19
XLogP 1.61
PSA 56.209
NB_HD 2
NB_HA 4
fsp3 0.60
Lipinski(0=no;1=yes) 1

FDA
NDA 019451 (pdf not found) INN (CHLORTHALIDONE ; METOPROLOL TARTRATE) LOPRESSIDONE (NOVARTIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 074380 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017963 (pdf not found) INN (METOPROLOL TARTRATE) LOPRESSOR (VALIDUS PHARMS) APPROVAL= AP YEAR= 1978
NDA 018303 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METOPROLOL TARTRATE) LOPRESSOR HCT (VALIDUS PHARMS) APPROVAL= AP YEAR= 1984
NDA 018704 (pdf not found) INN (METOPROLOL TARTRATE) LOPRESSOR (NOVARTIS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 019786 (pdf not found) INN (METOPROLOL FUMARATE) LOPRESSOR (NOVARTIS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019962 (pdf not found) INN (METOPROLOL SUCCINATE) TOPROL-XL (TOPROL) APPROVAL= AP YEAR= 1992
NDA 073653 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (MUTUAL PHARM) APPROVAL= AP YEAR= 1993 OBSOLETE
NDA 073654 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 073666 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074032 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (WATSON LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074133 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 073288 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (CHARTWELL RX) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 073289 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (CHARTWELL RX) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074143 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (TEVA) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074217 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (WATSON LABS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074258 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (APOTHECON) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074333 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (TEVA PHARMS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074141 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (HERITAGE PHARMA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074453 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (RENATA) APPROVAL= AP YEAR= 1995
NDA 074644 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 1996
NDA 075160 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (HOSPIRA) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 076495 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (HIKMA) APPROVAL= AP YEAR= 2003
NDA 076670 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076704 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (MYLAN) APPROVAL= AP YEAR= 2004
NDA 076792 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METOPROLOL TARTRATE) METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (MYLAN) APPROVAL= AP YEAR= 2004
NDA 021956 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METOPROLOL SUCCINATE) DUTOPROL (CONCORDIA) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076969 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (SANDOZ) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076640 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (NESHER PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077360 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (SANDOZ) APPROVAL= AP YEAR= 2007
NDA 077739 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2007
NDA 077761 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2007
NDA 077176 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (NESHER PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 077779 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (NESHER PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078085 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (HOSPIRA) APPROVAL= AP YEAR= 2008
NDA 078459 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (IPCA LABS LTD) APPROVAL= AP YEAR= 2008
NDA 076862 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2009
NDA 077118 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2009 OBSOLETE
NDA 090386 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (AM REGENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077298 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090317 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090615 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 2010
NDA 091045 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2010
NDA 091307 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (LUITPOLD) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 202033 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2011
NDA 090654 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METOPROLOL TARTRATE) METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (SUN PHARM INDS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078889 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (REDDYS) APPROVAL= AP YEAR= 2012
NDA 090617 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2012
NDA 078950 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2013
NDA 202870 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METOPROLOL TARTRATE) METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (ALEMBIC) APPROVAL= AP YEAR= 2013
NDA 202871 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (ALEMBIC PHARMS LTD) APPROVAL= AP YEAR= 2013
NDA 200981 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2014
NDA 204205 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (GLAND) APPROVAL= AP YEAR= 2014
NDA 204161 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2016
NDA 203894 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 204106 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (NOVAST LABS) APPROVAL= AP YEAR= 2018
NDA 210428 (pdf not found) INN (METOPROLOL SUCCINATE) KAPSPARGO SPRINKLE (SPIL) APPROVAL= AP YEAR= 2018
NDA 207206 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (VISUM PHARM) APPROVAL= AP YEAR= 2018
NDA 207465 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (CIPLA) APPROVAL= AP YEAR= 2018
NDA 203028 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (PHARMADAX INC) APPROVAL= AP YEAR= 2020
NDA 203699 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (PHARMADAX INC) APPROVAL= AP YEAR= 2020
NDA 208955 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2020
NDA 205541 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2020
NDA 211143 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2020
NDA 213854 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (YICHANG HUMANWELL) APPROVAL= AP YEAR= 2021
NDA 210597 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (PRINSTON INC) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 214004 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (SUNSHINE) APPROVAL= AP YEAR= 2022
NDA 215637 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 212402 (pdf not found) INN (METOPROLOL TARTRATE) METOPROLOL TARTRATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 216916 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (GRANULES) APPROVAL= AP YEAR= 2023
NDA 209272 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (LUPIN) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 216509 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (GRANULES) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 214110 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (ZHEJIANG JUTAI PHARM) APPROVAL= AP YEAR= 2024
NDA 206980 (pdf not found) INN (METOPROLOL SUCCINATE) METOPROLOL SUCCINATE (IPCA LABS LTD) APPROVAL= AP YEAR= 2025
NDA 215789 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METOPROLOL TARTRATE) METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (SENORES PHARMS) APPROVAL= AP YEAR= 2025
NDA 219373 (pdf not found) INN (METOPROLOL TARTRATE) LOPRESSOR (RUBICON RESEARCH) APPROVAL= AP YEAR= 2025

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL