e-Drug3D

467

TRIAZOLAM

INN
TRIAZOLAM

cas 28911-01-5

CLASS

NERVOUS SYSTEM
ANXIOLYTIC
BENZODIAZEPINES
GABA MODULATORS
A TRIAZOLOBENZODIAZEPINE HYPNOTIC AGENT

ROUTE (list)

ORAL

ATC code

N05CD05

PK parameters

Tmax 2 HOUR
VD 37.7 LITER (65 KILOGRAM)
Cl 11.7 LITER / HOUR (65 KILOGRAM)
PPB 90 PERCENT
t1/2 3.5 HOUR

Solubility

POORLY SOLUBLE IN WATER

Target

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR (GABA)

DrugCentral

GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1

GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2

Download SDF file

8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Formula:
C17H12Cl2N4

Calculated chemical properties:

MW 343.21
NB_atoms 23
XLogP 4.23
PSA 38.113
NB_HD 0
NB_HA 4
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 017892 (pdf not found) INN (TRIAZOLAM) HALCION (PFIZER) APPROVAL= AP YEAR= 1982
NDA 074031 (pdf not found) INN (TRIAZOLAM) TRIAZOLAM (PHARMOBEDIENT) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074224 (pdf not found) INN (TRIAZOLAM) TRIAZOLAM (HIKMA) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074445 (pdf not found) INN (TRIAZOLAM) TRIAZOLAM (WATSON LABS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 214219 (pdf not found) INN (TRIAZOLAM) TRIAZOLAM (NOVAST LABS) APPROVAL= AP YEAR= 2020
NDA 213003 (pdf not found) INN (TRIAZOLAM) TRIAZOLAM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022
NDA 216890 (pdf not found) INN (TRIAZOLAM) TRIAZOLAM (BRECKENRIDGE) APPROVAL= AP YEAR= 2022