e-Drug3D
459
ETIDRONATE
DISCONTINUED
INN
ETIDRONATE
cas 2809-21-4
CLASS
METABOLISM
BONE RESORPTION INHIBITOR
ANTIHYPOCALCEMIC AGENTS
BISPHOSPHONATES
OSTEOPOROSIS PROPHYLACTIC
IT CAN INHIBIT THE FORMATION GROWTH AND DISSOLUTION OF HYDROXYAPATITE CRYSTALS AND THEIR AMORPHOUS PRECURSORS BY CHEMISORPTION TO CALCIUM PHOSPHATE SURFACES
ROUTE (list)
ORAL INJECTION
PK parameters
F 3 PERCENT
t1/2 3.5 HOUR
Solubility
HIGHLY SOLUBLE IN WATER
TARGET FARNESYL PYROPHOSPHATE SYNTHASE
PDB
3SDV (STRUCTURE OF A THREE-DOMAIN SESQUITERPENE SYNTHASE: A PROSPECTIVE TARGET FOR ADVANCED BIOFUELS PRODUCTION)
Ligand code = 911 (link to the list of PDB complexes)
Download experimental 3D coordinates of 911 with added hydrogens
Type IV secretion-like conjugative transfer relaxase protein TraI UNIPROT B1LRJ1 traI
Formula:
C2H8O7P2
Calculated chemical properties:
MW 201.99
NB_atoms 11
XLogP -3.52
PSA 134.201
NB_HD 1
NB_HA 7
fsp3 1.00
Lipinski(0=no;1=yes) 1
NB_atoms 11
XLogP -3.52
PSA 134.201
NB_HD 1
NB_HA 7
fsp3 1.00
Lipinski(0=no;1=yes) 1
FDA
NDA 017831 (pdf not found) INN (ETIDRONATE DISODIUM) DIDRONEL (APIL) APPROVAL= AP YEAR= 1977 NEWMOLECULARENTITY DISCONTINUED
NDA 019545 (pdf not found) INN (ETIDRONATE DISODIUM) DIDRONEL (MGI PHARMA INC) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 075800 (pdf not found) INN (ETIDRONATE DISODIUM) ETIDRONATE DISODIUM (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 017831 (pdf not found) INN (ETIDRONATE DISODIUM) DIDRONEL (APIL) APPROVAL= AP YEAR= 1977 NEWMOLECULARENTITY DISCONTINUED
NDA 019545 (pdf not found) INN (ETIDRONATE DISODIUM) DIDRONEL (MGI PHARMA INC) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 075800 (pdf not found) INN (ETIDRONATE DISODIUM) ETIDRONATE DISODIUM (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2003 DISCONTINUED