e-Drug3D

458

cas 303-53-7

CLASS

MUSCULO-SKELETAL
MUSCLE RELAXANT (SKELETAL)
RELIEVES SKELETAL MUSCLE SPASM OF LOCAL ORIGIN WITHOUT INTERFERING WITH MUSCLE FUNCTION
5-HT2 RECEPTOR ANTAGONIST (PMID12498911)
STRUCTURAL ANALOG OF TRICYCLIC ANTIDEPRESSANTS

ROUTE (list)

ORAL SUBLINGUAL

PK parameters

F 44 PERCENT
Tmax 7.1 HOUR
Cl 42 LITER / HOUR
t1/2 32 HOUR

MW 275.38
NB_atoms 21
XLogP 4.55
PSA 6.005
NB_HD 0
NB_HA 1
fsp3 0.20
Lipinski(0=no;1=yes) 1

FDA
NDA 017821 (label) INN (CYCLOBENZAPRINE HYDROCHLORIDE) FLEXERIL (JANSSEN RES AND DEV) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 071611 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 1988
NDA 072854 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (AIPING PHARM INC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073143 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073144 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073683 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074436 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 073541 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (ANDA REPOSITORY) APPROVAL= AP YEAR= 1995
NDA 074421 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (PLIVA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 077209 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 2005
NDA 077291 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (PROSAM LABS) APPROVAL= AP YEAR= 2005 DISCONTINUED OBSOLETE
NDA 077563 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (JUBILANT CADISTA) APPROVAL= AP YEAR= 2006
NDA 021777 (label) INN (CYCLOBENZAPRINE HYDROCHLORIDE) AMRIX (TEVA PHARMS INTL) APPROVAL= AP YEAR= 2007
NDA 077797 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (PRINSTON INC) APPROVAL= AP YEAR= 2007
NDA 078218 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2008
NDA 078722 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2008
NDA 078643 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2008
NDA 090478 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2010
NDA 078048 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (KVK TECH) APPROVAL= AP YEAR= 2011
NDA 090738 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2011 OBSOLETE
NDA 090864 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (PAR PHARM INC) APPROVAL= TA YEAR= 2013
NDA 091281 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (TWI PHARMS INC) APPROVAL= AP YEAR= 2013
NDA 208170 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2017
NDA 206703 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 213324 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2020
NDA 207314 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 214732 (label) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (NOVAST LABS) APPROVAL= AP YEAR= 2024
NDA 218936 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) CYCLOBENZAPRINE HYDROCHLORIDE (GRAVITI PHARMS) APPROVAL= AP YEAR= 2024
NDA 219428 (pdf not found) INN (CYCLOBENZAPRINE HYDROCHLORIDE) TONMYA (TONIX) APPROVAL= AP YEAR= 2025