e-Drug3D

456

DINOPROSTONE

INN
DINOPROSTONE

cas 363-24-6

CLASS

GENITO
PROSTAGLANDIN
OXYTOCIC
NATURALLY OCCURRING FORM OF PROSTAGLANDIN E2 (PGE2)

ROUTE (list)

VAGINAL ENDOCERVICAL

ATC code

G02AD02

PK parameters

Tmax 0.62 HOUR
t1/2 0.06 HOUR

Solubility

IN WATER 130 MILLIGRAM / 100 MILLILITER

Target

TARGET PROSTAGLANDIN E2 RECEPTOR EP2

PDB
3WFH (CRYSTAL STRUCTURE OF ANTI-PROSTAGLANDIN E2 FAB FRAGMENT PGE2 COMPLEX)

Ligand code = P2E (link to the list of PDB complexes)

Download experimental 3D coordinates of P2E with added hydrogens

DrugCentral

Prostaglandin E2 receptor EP1 subtype UNIPROT P34995 PTGER1

Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3

Download SDF file

7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid

Formula:
C20H32O5

Calculated chemical properties:

MW 351.45
NB_atoms 25
XLogP 1.92
PSA 91.659
NB_HD 2
NB_HA 5
fsp3 0.70
Lipinski(0=no;1=yes) 1

FDA
NDA 017810 (pdf not found) INN (DINOPROSTONE) PROSTIN E2 (PFIZER) APPROVAL= AP YEAR= 1977 NEWMOLECULARENTITY DISCONTINUED
NDA 019617 (pdf not found) INN (DINOPROSTONE) PREPIDIL (PFIZER) APPROVAL= AP YEAR= 1992
NDA 020411 (pdf not found) INN (DINOPROSTONE) CERVIDIL (FERRING PHARMS INC) APPROVAL= AP YEAR= 1995