e-Drug3D

452

DIFENOXIN

INN
DIFENOXIN

cas 28782-42-5

CLASS

METABOLISM
ANTIPERISTALTIC
ANTIDIARRHEAL AGENT
CHEMICALLY RELATED TO THE NARCOTIC MEPERIDINE
INHIBIT NET FLUID SECRETION BY INDIRECT MECHANISMS (PMID8386327)

ROUTE (list)

ORAL

ATC code

A07DA04

PK parameters

Tmax 0.83 HOUR
t1/2 13 HOUR

Target

TARGET MU-TYPE OPIOID RECEPTOR

DrugCentral

Mu-type opioid receptor UNIPROT P35372 OPRM1

Download SDF file

1-[3-cyano-3,3-di(phenyl)propyl]-4-phenylpiperidine-4-carboxylic acid

Formula:
C28H28N2O2

Calculated chemical properties:

MW 423.52
NB_atoms 32
XLogP 3.67
PSA 55.373
NB_HD 0
NB_HA 4
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 017744 (label) INN (ATROPINE SULFATE ; DIFENOXIN HYDROCHLORIDE) MOTOFEN HALF-STRENGTH (SEBELA IRELAND LTD) APPROVAL= AP YEAR= 1978