e-Drug3D

448

cas 26171-23-3

CLASS

MUSCULO-SKELETAL
ANTIINFLAMMATORY
CYCLOOXYGENASE INHIBITORS
NSAID
ANALGESIC
ANTI-INFLAMMATORY
ANTIPYRETIC
TREATMENT OF RHEUMATOID ARTHRITIS

ROUTE (list)

ORAL

PK parameters

F 100 PERCENT
Tmax 0.75 HOUR

TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB
3S3G (CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH TOLMETIN)

Ligand code = TLT (link to the list of PDB complexes)

Download experimental 3D coordinates of TLT with added hydrogens

MW 256.27
NB_atoms 19
XLogP 0.86
PSA 53.935
NB_HD 0
NB_HA 4
fsp3 0.20
Lipinski(0=no;1=yes) 1

FDA
NDA 017628 (label) INN (TOLMETIN SODIUM) TOLECTIN (ORTHO MCNEIL JANSSEN) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 018084 (label) INN (TOLMETIN SODIUM) TOLECTIN DS (ORTHO MCNEIL JANSSEN) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 073290 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (TEVA) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073310 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073311 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073308 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073392 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073462 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (CHARTWELL RX) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073519 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073527 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073588 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (CHARTWELL RX) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073393 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (RISING) APPROVAL= AP YEAR= 1993
NDA 074002 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (CHARTWELL RX) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074473 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (RISING) APPROVAL= AP YEAR= 1994
NDA 074399 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (COSETTE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074729 (pdf not found) INN (TOLMETIN SODIUM) TOLMETIN SODIUM (COSETTE) APPROVAL= AP YEAR= 1997 DISCONTINUED