e-Drug3D

446

cas 23593-75-1

CLASS

DERMATOLOGICALS
ANTIFUNGAL
ANTI-INFECTIVE
IMIDAZOLE CLASS
INHIBIT 14-ALPHA-DEMETHYLATION OF LANOSTEROL IN FUNGI

ROUTE (list)

TOPICAL VAGINAL ORAL

PK parameters

Tmax 0.5 HOUR

TARGET CYTOCHROME P450 51

PDB
2XFH (STRUCTURE OF CYTOCHROME P450 ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE.)

Ligand code = CL6 (link to the list of PDB complexes)

Download experimental 3D coordinates of CL6 with added hydrogens

MW 344.83
NB_atoms 25
XLogP 5.38
PSA 12.76
NB_HD 0
NB_HA 2
fsp3 0.05
Lipinski(0=no;1=yes) 0

FDA
NDA 019069 (pdf not found) INN (CLOTRIMAZOLE) MYCELEX-G (BAYER PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017613 (pdf not found) INN (CLOTRIMAZOLE) LOTRIMIN (SCHERING PLOUGH) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 017619 (pdf not found) INN (CLOTRIMAZOLE) LOTRIMIN (SCHERING PLOUGH) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 017717 (pdf not found) INN (CLOTRIMAZOLE) GYNE-LOTRIMIN (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 018052 (label) INN (CLOTRIMAZOLE) GYNE-LOTRIMIN (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 018181 (pdf not found) INN (CLOTRIMAZOLE) MYCELEX (BAYER HLTHCARE) APPROVAL= AP YEAR= 1979
NDA 018182 (pdf not found) INN (CLOTRIMAZOLE) MYCELEX-7 (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 018183 (pdf not found) INN (CLOTRIMAZOLE) MYCELEX (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 018230 (pdf not found) INN (CLOTRIMAZOLE) MYCELEX-7 (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 018713 (label) INN (CLOTRIMAZOLE) MYCELEX (BAYER HLTHCARE) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 018813 (pdf not found) INN (CLOTRIMAZOLE) LOTRIMIN (SCHERING) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 018827 (label) INN (BETAMETHASONE DIPROPIONATE ; CLOTRIMAZOLE) LOTRISONE (ORGANON) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 020888 (label) INN (CLOTRIMAZOLE) LOTRIMIN AF (SCHERING PLOUGH) APPROVAL= AP YEAR= 1989
NDA 020889 (label) INN (CLOTRIMAZOLE) LOTRIMIN AF (SCHERING PLOUGH) APPROVAL= AP YEAR= 1989
NDA 020890 (label) INN (CLOTRIMAZOLE) LOTRIMIN AF (SCHERING PLOUGH) APPROVAL= AP YEAR= 1989
NDA 020289 (pdf not found) INN (CLOTRIMAZOLE) GYNE-LOTRIMIN COMBINATION PACK (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072640 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (TARO) APPROVAL= AP YEAR= 1993
NDA 074165 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (P AND L) APPROVAL= AP YEAR= 1993
NDA 020389 (pdf not found) INN (CLOTRIMAZOLE) MYCELEX-7 COMBINATION PACK (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 072641 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (TARO) APPROVAL= AP YEAR= 1995
NDA 073306 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (TEVA) APPROVAL= AP YEAR= 1995
NDA 020525 (pdf not found) INN (CLOTRIMAZOLE) GYNE-LOTRIMIN 3 (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020526 (pdf not found) INN (CLOTRIMAZOLE) GYNE-LOTRIMIN 3 COMBINATION PACK (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074580 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (TARO) APPROVAL= AP YEAR= 1996
NDA 020574 (label) INN (CLOTRIMAZOLE) GYNE-LOTRIMIN 3 (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 073249 (pdf not found) INN (CLOTRIMAZOLE) GYNIX (TEVA PHARMS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 020010 (label) INN (BETAMETHASONE DIPROPIONATE ; CLOTRIMAZOLE) LOTRISONE (MERCK SHARP DOHME) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 021143 (label) INN (CLOTRIMAZOLE) TRIVAGIZOLE 3 (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2000
NDA 075502 (pdf not found) INN (BETAMETHASONE DIPROPIONATE ; CLOTRIMAZOLE) CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2001
NDA 075673 (pdf not found) INN (BETAMETHASONE DIPROPIONATE ; CLOTRIMAZOLE) CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE (TARO) APPROVAL= AP YEAR= 2001
NDA 076002 (pdf not found) INN (BETAMETHASONE DIPROPIONATE ; CLOTRIMAZOLE) CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 2002
NDA 076387 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (HIKMA) APPROVAL= AP YEAR= 2004
NDA 076493 (pdf not found) INN (BETAMETHASONE DIPROPIONATE ; CLOTRIMAZOLE) CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE (TARO) APPROVAL= AP YEAR= 2004
NDA 076516 (pdf not found) INN (BETAMETHASONE DIPROPIONATE ; CLOTRIMAZOLE) CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2005
NDA 076763 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (PADAGIS US) APPROVAL= AP YEAR= 2005
NDA 078338 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2008
NDA 090219 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (GLENMARK PHARMS) APPROVAL= AP YEAR= 2010
NDA 202894 (pdf not found) INN (BETAMETHASONE DIPROPIONATE ; CLOTRIMAZOLE) CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE (GLENMARK PHARMS) APPROVAL= AP YEAR= 2015
NDA 209815 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2019
NDA 212281 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (TRUPHARMA) APPROVAL= AP YEAR= 2019
NDA 216569 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 215641 (pdf not found) INN (CLOTRIMAZOLE) CLOTRIMAZOLE (THINQ PHARM-CRO PVT) APPROVAL= AP YEAR= 2024