e-Drug3D

440

cas 4342-03-4

CLASS

ANTINEOPLASTIC
ALKYLATING
HYPOTHESIS OF INHIBITION OF DNA SYNTHESIS BY ACTING AS A PURINE ANALOG

ROUTE (list)

INJECTION

PK parameters

VD 78 LITER (65 KILOGRAM)
Cl 10.1 LITER / HOUR (65 KILOGRAM)
PPB 0 PERCENT
t1/2 6.2 HOUR

MW 182.20
NB_atoms 13
XLogP -1.67
PSA 94.89
NB_HD 3
NB_HA 7
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 070821 (pdf not found) INN (DACARBAZINE) DACARBAZINE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070822 (pdf not found) INN (DACARBAZINE) DACARBAZINE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071563 (pdf not found) INN (DACARBAZINE) DACARBAZINE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017575 (pdf not found) INN (DACARBAZINE) DTIC-DOME (BAYER HLTHCARE) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 070962 (pdf not found) INN (DACARBAZINE) DACARBAZINE (ABRAXIS PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070990 (pdf not found) INN (DACARBAZINE) DACARBAZINE (ABRAXIS PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 075259 (pdf not found) INN (DACARBAZINE) DACARBAZINE (MEITHEAL) APPROVAL= AP YEAR= 1998
NDA 075371 (pdf not found) INN (DACARBAZINE) DACARBAZINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1999
NDA 075812 (pdf not found) INN (DACARBAZINE) DACARBAZINE (HIKMA) APPROVAL= AP YEAR= 2001
NDA 075940 (pdf not found) INN (DACARBAZINE) DACARBAZINE (HOSPIRA) APPROVAL= AP YEAR= 2001 DISCONTINUED