e-Drug3D

439

ISOFLURANE

INN
ISOFLURANE

cas 26675-46-7

CLASS

NERVOUS SYSTEM
ANESTHETIC

ROUTE (list)

INHALATION

ATC code

N01AB06

PK parameters

Target

TARGET CYS-LOOP FAMILY OF PENTAMERIC LIGAND-GATED ION CHANNELS (PLGIC)

PDB
3F78 (CRYSTAL STRUCTURE OF WILD TYPE LFA1 I DOMAIN COMPLEXED WITH ISOFLURANE)

Ligand code = ICF (link to the list of PDB complexes)

Download experimental 3D coordinates of ICF with added hydrogens

DrugCentral

Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2

Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3

Download SDF file

2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

Formula:
C3H2ClF5O

Calculated chemical properties:

MW 184.50
NB_atoms 10
XLogP 2.35
PSA 10.667
NB_HD 0
NB_HA 1
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 017624 (pdf not found) INN (ISOFLURANE) FORANE (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1979
NDA 074097 (pdf not found) INN (ISOFLURANE) ISOFLURANE (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074416 (pdf not found) INN (ISOFLURANE) ISOFLURANE (PIRAMAL CRITICAL) APPROVAL= AP YEAR= 1994
NDA 074393 (pdf not found) INN (ISOFLURANE) ISOFLURANE (WATSON LABS INC) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074502 (pdf not found) INN (ISOFLURANE) ISOFLURANE (PIRAMAL PHARMA) APPROVAL= AP YEAR= 1995
NDA 075225 (pdf not found) INN (ISOFLURANE) ISOFLURANE (HALOCARBON PRODS) APPROVAL= AP YEAR= 1999