e-Drug3D
435
DANAZOL
INN
DANAZOL
cas 17230-88-5
CLASS
GENITO
ANTERIOR PITUITARY SUPPRESSANT
NUCLEAR RECEPTOR ANTAGONISTS
ROUTE (list)
ORAL
ATC code
G03XA01
PK parameters
Tmax 4 HOUR
Cl 727 LITER / HOUR
t1/2 9.7 HOUR
Solubility
INSOLUBLE IN WATER
TARGET ESTROGEN RECEPTOR
PROGESTERONE RECEPTOR
ANDROGEN RECEPTOR
PROGESTERONE RECEPTOR
ANDROGEN RECEPTOR
PDB
6ULB (SEX HORMONE-BINDING GLOBULIN MUTANT E176K IN COMPLEX WITH DANAZOL)
Ligand code = QA1 (link to the list of PDB complexes)
Download experimental 3D coordinates of QA1 with added hydrogens
Androgen receptor UNIPROT P10275 AR
Progesterone receptor UNIPROT P06401 PGR
Formula:
C22H27NO2
Calculated chemical properties:
MW 337.45
NB_atoms 25
XLogP 4.22
PSA 42.721
NB_HD 1
NB_HA 3
fsp3 0.68
Lipinski(0=no;1=yes) 1
NB_atoms 25
XLogP 4.22
PSA 42.721
NB_HD 1
NB_HA 3
fsp3 0.68
Lipinski(0=no;1=yes) 1
FDA
NDA 071569 (pdf not found) INN (DANAZOL) DANAZOL (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017557 (label) INN (DANAZOL) DANOCRINE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 074582 (pdf not found) INN (DANAZOL) DANAZOL (BARR) APPROVAL= AP YEAR= 1996
NDA 077246 (pdf not found) INN (DANAZOL) DANAZOL (LANNETT CO INC) APPROVAL= AP YEAR= 2005
NDA 078214 (pdf not found) INN (DANAZOL) DANAZOL (LANNETT) APPROVAL= AP YEAR= 2007
NDA 071569 (pdf not found) INN (DANAZOL) DANAZOL (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017557 (label) INN (DANAZOL) DANOCRINE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 074582 (pdf not found) INN (DANAZOL) DANAZOL (BARR) APPROVAL= AP YEAR= 1996
NDA 077246 (pdf not found) INN (DANAZOL) DANAZOL (LANNETT CO INC) APPROVAL= AP YEAR= 2005
NDA 078214 (pdf not found) INN (DANAZOL) DANAZOL (LANNETT) APPROVAL= AP YEAR= 2007