e-Drug3D

433

cas 28860-95-9

CLASS

NERVOUS SYSTEM
ENZYME INHIBITOR (DECARBOXYLASE)
ANTIDYSKINETICS
ANTIPARKINSON AGENTS

ROUTE (list)

ORAL ENTERAL

PK parameters

F 99 PERCENT
Tmax 2.95 HOUR
PPB 36 PERCENT
t1/2 1.8 HOUR

TARGET AROMATIC-L-AMINO-ACID DECARBOXYLASE (AADC)

PDB
1JS3 (CRYSTAL STRUCTURE OF DOPA DECARBOXYLASE IN COMPLEX WITH THE INHIBITOR CARBIDOPA)

Ligand code = 142 (link to the list of PDB complexes)

Download experimental 3D coordinates of 142 with added hydrogens

MW 225.22
NB_atoms 16
XLogP -1.39
PSA 113.497
NB_HD 5
NB_HA 6
fsp3 0.30
Lipinski(0=no;1=yes) 1

FDA
NDA 073381 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073382 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073383 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017555 (pdf not found) INN (CARBIDOPA ; LEVODOPA) SINEMET (ORGANON) APPROVAL= AP YEAR= 1975
NDA 017830 (pdf not found) INN (CARBIDOPA) LODOSYN (ATON) APPROVAL= AP YEAR= 1977
NDA 019856 (pdf not found) INN (CARBIDOPA ; LEVODOPA) SINEMET CR (ORGANON LLC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073589 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 073607 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 073618 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 074260 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1993
NDA 074080 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 073586 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073587 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ANI PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073620 (pdf not found) INN (CARBIDOPA) CARBIDOPA AND LEVODOPA (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1995 DISCONTINUED OBSOLETE
NDA 075091 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (MYLAN) APPROVAL= AP YEAR= 1999
NDA 021485 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) STALEVO 50 (ORION PHARMA) APPROVAL= AP YEAR= 2003
NDA 076212 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (APOTEX) APPROVAL= AP YEAR= 2004
NDA 076521 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IMPAX LABS) APPROVAL= AP YEAR= 2004
NDA 076663 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (KV PHARM) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076699 (pdf not found) INN (CARBIDOPA ; LEVODOPA) PARCOPA (UCB INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076643 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBILEV (RANBAXY) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077828 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM INDS) APPROVAL= AP YEAR= 2007
NDA 077120 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (APOTEX INC) APPROVAL= AP YEAR= 2008
NDA 078893 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RISING) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078536 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM INDS) APPROVAL= AP YEAR= 2008
NDA 078690 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM) APPROVAL= AP YEAR= 2009
NDA 090324 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (MYLAN) APPROVAL= AP YEAR= 2009
NDA 090631 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IMPAX LABS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 079085 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (SUN PHARM) APPROVAL= AP YEAR= 2012
NDA 090786 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (WOCKHARDT LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090833 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (WOCKHARDT LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202323 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013
NDA 203261 (pdf not found) INN (CARBIDOPA) CARBIDOPA (ANI PHARMS) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203312 (pdf not found) INN (CARBIDOPA ; LEVODOPA) RYTARY (IMPAX) APPROVAL= AP YEAR= 2015
NDA 203952 (pdf not found) INN (CARBIDOPA ; LEVODOPA) DUOPA (ABBVIE) APPROVAL= AP YEAR= 2015
NDA 204291 (pdf not found) INN (CARBIDOPA) CARBIDOPA (ALVOGEN) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 205304 (pdf not found) INN (CARBIDOPA) CARBIDOPA (EDENBRIDGE PHARMS) APPROVAL= AP YEAR= 2016
NDA 204763 (pdf not found) INN (CARBIDOPA) CARBIDOPA (NOVEL LABS INC) APPROVAL= AP YEAR= 2017
NDA 209910 (pdf not found) INN (CARBIDOPA) CARBIDOPA (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 210341 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 211055 (pdf not found) INN (CARBIDOPA) CARBIDOPA (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2019
NDA 203424 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (MYLAN) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214092 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 214091 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 214869 (pdf not found) INN (CARBIDOPA ; LEVODOPA) DHIVY (AVION PHARMS) APPROVAL= AP YEAR= 2021
NDA 213212 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (RISING) APPROVAL= AP YEAR= 2022
NDA 216505 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RUBICON) APPROVAL= AP YEAR= 2022
NDA 216537 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 208895 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA; LEVODOPA (SANDOZ INC) APPROVAL= TA YEAR= 2023
NDA 215999 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 217961 (pdf not found) INN (CARBIDOPA) CARBIDOPA (BEXIMCO PHARMS USA) APPROVAL= AP YEAR= 2023
NDA 217482 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RUBICON) APPROVAL= AP YEAR= 2024
NDA 217186 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CREXONT (IMPAX) APPROVAL= AP YEAR= 2024
NDA 210911 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA; LEODOPA (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2025
NDA 214495 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025
NDA 218939 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2025
NDA 219231 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2025