e-Drug3D

432

cas 10262-69-8

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANT
NOREPINEPHRINE UPTAKE INHIBITORS

ROUTE (list)

ORAL

PK parameters

VD 2925 LITER (65 KILOGRAM)
Cl 54.6 LITER / HOUR (65 KILOGRAM)
PPB 89 PERCENT
t1/2 51 HOUR

TARGET NORADRENALINE TRANSPORTER

PDB
8Y8Z (STRUCTURE OF NET-MAPROTILINE IN OUTWARD-OPEN STATE)

Ligand code = A1LX3 (link to the list of PDB complexes)

Download experimental 3D coordinates of A1LX3 with added hydrogens

MW 277.39
NB_atoms 21
XLogP 4.21
PSA 14.519
NB_HD 1
NB_HA 1
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 071943 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071944 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071945 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072129 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072130 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072131 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017543 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) LUDIOMIL (NOVARTIS) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 072162 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072163 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072164 (pdf not found) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072285 (label) INN (MAPROTILINE HYDROCHLORIDE) MAPROTILINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 1988 DISCONTINUED