e-Drug3D
426
LOXAPINE
INN
LOXAPINE
cas 1977-10-2
CLASS
NERVOUS SYSTEM
ANXIOLYTIC
DIBENZOXAZEPINE ANTIPSYCHOTIC AGENTS
DOPAMINE ANTAGONISTS
TREATMENT OF SCHIZOPHRENIA
ROUTE (list)
ORAL INJECTION INHALATION
ATC code
N05AH01
PK parameters
Tmax 1.88 HOUR
Cl 48.4 LITER / HOUR
PPB 96.6 PERCENT
t1/2 7.3 HOUR
TARGET D(2) DOPAMINE RECEPTOR
SEROTONIN 5-HT2 RECEPTOR (PMID24937085)
D(2) dopamine receptor UNIPROT P14416 DRD2
5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A
Formula:
C18H18ClN3O
Calculated chemical properties:
MW 327.80
NB_atoms 23
XLogP 3.77
PSA 27.447
NB_HD 0
NB_HA 4
fsp3 0.28
Lipinski(0=no;1=yes) 1
NB_atoms 23
XLogP 3.77
PSA 27.447
NB_HD 0
NB_HA 4
fsp3 0.28
Lipinski(0=no;1=yes) 1
FDA
NDA 017525 (pdf not found) INN (LOXAPINE SUCCINATE) LOXITANE (TEVA BRANDED PHARM) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 017658 (pdf not found) INN (LOXAPINE HYDROCHLORIDE) LOXITANE C (TEVA BRANDED PHARM) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 018039 (pdf not found) INN (LOXAPINE HYDROCHLORIDE) LOXITANE IM (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 072062 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072204 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072205 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072206 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 076762 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (RISING) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076868 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (ELITE LABS INC) APPROVAL= AP YEAR= 2005
NDA 090695 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (LANNETT CO INC) APPROVAL= AP YEAR= 2011
NDA 022549 (pdf not found) INN (LOXAPINE) ADASUVE (ALEXZA PHARMS) APPROVAL= AP YEAR= 2012
NDA 017525 (pdf not found) INN (LOXAPINE SUCCINATE) LOXITANE (TEVA BRANDED PHARM) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 017658 (pdf not found) INN (LOXAPINE HYDROCHLORIDE) LOXITANE C (TEVA BRANDED PHARM) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 018039 (pdf not found) INN (LOXAPINE HYDROCHLORIDE) LOXITANE IM (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 072062 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072204 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072205 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072206 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 076762 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (RISING) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076868 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (ELITE LABS INC) APPROVAL= AP YEAR= 2005
NDA 090695 (pdf not found) INN (LOXAPINE SUCCINATE) LOXAPINE SUCCINATE (LANNETT CO INC) APPROVAL= AP YEAR= 2011
NDA 022549 (pdf not found) INN (LOXAPINE) ADASUVE (ALEXZA PHARMS) APPROVAL= AP YEAR= 2012