e-Drug3D
425
MEBENDAZOLE
INN
MEBENDAZOLE
cas 31431-39-7
CLASS
ANTIPARASITIC
ANTHELMINTIC
ANTINEMATODAL AGENTS
INHIBITS THE FORMATION OF THE WORMS' MICROTUBULES
ROUTE (list)
ORAL
PK parameters
VD 78 LITER (65 KILOGRAM)
Cl 58.5 LITER / HOUR (65 KILOGRAM)
PPB 91 PERCENT
t1/2 1.1 HOUR
Solubility
LESS THAN 0.05 PERCENT SOLUBLE IN WATER
TARGET TUBULIN
PDB
7OGN (CRYSTAL STRUCTURE OF T2R-TTL -MEBENDAZOLE COMPLEX)
Ligand code = V95 (link to the list of PDB complexes)
Download experimental 3D coordinates of V95 with added hydrogens
Tubulin UNIPROT C4PKY4
Tubulin UNIPROT F1L005
Formula:
C16H13N3O3
Calculated chemical properties:
MW 295.29
NB_atoms 22
XLogP 2.97
PSA 77.779
NB_HD 2
NB_HA 6
fsp3 0.06
Lipinski(0=no;1=yes) 1
NB_atoms 22
XLogP 2.97
PSA 77.779
NB_HD 2
NB_HA 6
fsp3 0.06
Lipinski(0=no;1=yes) 1
FDA
NDA 017481 (pdf not found) INN (MEBENDAZOLE) VERMOX (JANSSEN PHARMS) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 073580 (pdf not found) INN (MEBENDAZOLE) EMVERM (IMPAX LABS INC) APPROVAL= AP YEAR= 1995
NDA 208398 (pdf not found) INN (MEBENDAZOLE) VERMOX (JANSSEN PHARMS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 017481 (pdf not found) INN (MEBENDAZOLE) VERMOX (JANSSEN PHARMS) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 073580 (pdf not found) INN (MEBENDAZOLE) EMVERM (IMPAX LABS INC) APPROVAL= AP YEAR= 1995
NDA 208398 (pdf not found) INN (MEBENDAZOLE) VERMOX (JANSSEN PHARMS) APPROVAL= AP YEAR= 2016 DISCONTINUED