e-Drug3D

424

PIMOZIDE

INN
PIMOZIDE

cas 2062-78-4

CLASS

NERVOUS SYSTEM
ANTIPSYCHOTIC
ANTI-DYSKINESIA AGENTS
DOPAMINE ANTAGONISTS

ROUTE (list)

ORAL

ATC code

N05AG02

PK parameters

F 50 PERCENT
Tmax 7 HOUR
VD 1833 LITER (65 KILOGRAM)
Cl 16 LITER / HOUR (65 KILOGRAM)
t1/2 55 HOUR

Solubility

IN WATER LESS THAN 0.01 MILLIGRAM / MILLILITER

Target

TARGET D(2) DOPAMINE RECEPTOR

PDB
8GU1 (CRYSTAL STRUCTURE OF PUTATIVE AMINO ACID BINDING PERIPLASMIC ABC TRANSPORTER PROTEIN FROM CANDIDATUS LIBERIBACTER ASIATICUS IN COMPLEX WITH PIMOZIDE)

Ligand code = 1II (link to the list of PDB complexes)

Download experimental 3D coordinates of 1II with added hydrogens

DrugCentral

D(2) dopamine receptor UNIPROT P14416 DRD2

Download SDF file

3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one

Formula:
C28H29F2N3O

Calculated chemical properties:

MW 461.54
NB_atoms 34
XLogP 5.86
PSA 37.096
NB_HD 1
NB_HA 4
fsp3 0.32
Lipinski(0=no;1=yes) 0

FDA
NDA 017473 (pdf not found) INN (PIMOZIDE) ORAP (TEVA) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 204521 (pdf not found) INN (PIMOZIDE) PIMOZIDE (PH HEALTH) APPROVAL= AP YEAR= 2015