e-Drug3D

419

cas 19216-56-9

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC ALPHA-ANTAGONISTS
ALPHA-ADRENERGIC BLOCKING AGENTS

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT
Tmax 3 HOUR
VD 47 LITER (65 KILOGRAM)
Cl 18.3 LITER / HOUR (65 KILOGRAM)
PPB 94 PERCENT
t1/2 2.5 HOUR

TARGET ALPHA-1A ADRENERGIC RECEPTOR
ALPHA-1B ADRENERGIC RECEPTOR
ALPHA-1D ADRENERGIC RECEPTOR

PDB
3OWX (X-RAY STRUCTURAL STUDY OF QUINONE REDUCTASE II INHIBITION BY COMPOUNDS WITH MICROMOLAR TO NANOMOLAR RANGE IC50 VALUES)

Ligand code = XRA (link to the list of PDB complexes)

Download experimental 3D coordinates of XRA with added hydrogens

MW 383.41
NB_atoms 28
XLogP 1.78
PSA 94.938
NB_HD 2
NB_HA 9
fsp3 0.32
Lipinski(0=no;1=yes) 1

FDA
NDA 072782 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072783 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072784 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072921 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072991 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072992 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017442 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) MINIPRESS (PFIZER) APPROVAL= AP YEAR= 1976
NDA 017986 (pdf not found) INN (POLYTHIAZIDE ; PRAZOSIN HYDROCHLORIDE) MINIZIDE (PFIZER) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 071745 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 1988
NDA 071994 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1988
NDA 071995 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 1988
NDA 072333 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072352 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072573 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1989
NDA 072574 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1989
NDA 072575 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1989
NDA 072576 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1989 DISCONTINUED OBSOLETE
NDA 072577 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072578 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1989 DISCONTINUED OBSOLETE
NDA 072609 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072705 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (DAVA PHARMS INC) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072706 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (DAVA PHARMS INC) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072707 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (DAVA PHARMS INC) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019775 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) MINIPRESS XL (PFIZER) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 210971 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2018
NDA 214608 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (GRANULES) APPROVAL= AP YEAR= 2021
NDA 213406 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (APPCO) APPROVAL= AP YEAR= 2022
NDA 215697 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 213052 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 217268 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2023
NDA 214083 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 216727 (pdf not found) INN (PRAZOSIN HYDROCHLORIDE) PRAZOSIN HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2024