e-Drug3D
411
METOLAZONE
INN
METOLAZONE
cas 17560-51-9
CLASS
CARDIOVASCULAR
QUINAZOLINE DIURETIC
ANTIHYPERTENSIVE
BLOCKER
ROUTE (list)
ORAL
PK parameters
VD 104 LITER (65 KILOGRAM)
Cl 5.4 LITER / HOUR (65 KILOGRAM)
PPB 95 PERCENT
t1/2 14 HOUR
Solubility
SPARINGLY SOLUBLE IN WATER
TARGET NA-CL COTRANSPORTER (NCC)
Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3
Formula:
C16H16ClN3O3S
Calculated chemical properties:
MW 365.84
NB_atoms 24
XLogP 2.71
PSA 88.748
NB_HD 3
NB_HA 6
fsp3 0.19
Lipinski(0=no;1=yes) 1
NB_atoms 24
XLogP 2.71
PSA 88.748
NB_HD 3
NB_HA 6
fsp3 0.19
Lipinski(0=no;1=yes) 1
FDA
NDA 017386 (pdf not found) INN (METOLAZONE) ZAROXOLYN (I3 PHARMS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 018535 (pdf not found) INN (METOLAZONE) DIULO (GD SEARLE LLC) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 019532 (pdf not found) INN (METOLAZONE) MYKROX (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 075543 (pdf not found) INN (METOLAZONE) METOLAZONE (ANI PHARMS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076466 (pdf not found) INN (METOLAZONE) METOLAZONE (SANDOZ) APPROVAL= AP YEAR= 2003
NDA 076698 (pdf not found) INN (METOLAZONE) METOLAZONE (MYLAN) APPROVAL= AP YEAR= 2003
NDA 076732 (pdf not found) INN (METOLAZONE) METOLAZONE (SANDOZ) APPROVAL= AP YEAR= 2003
NDA 076482 (pdf not found) INN (METOLAZONE) METOLAZONE (ROXANE) APPROVAL= AP YEAR= 2004
NDA 076600 (pdf not found) INN (METOLAZONE) METOLAZONE (TEVA) APPROVAL= AP YEAR= 2004 DISCONTINUED OBSOLETE
NDA 076833 (pdf not found) INN (METOLAZONE) METOLAZONE (TEVA) APPROVAL= AP YEAR= 2004 DISCONTINUED OBSOLETE
NDA 076891 (pdf not found) INN (METOLAZONE) METOLAZONE (WATSON LABS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 213251 (pdf not found) INN (METOLAZONE) METOLAZONE (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 213827 (pdf not found) INN (METOLAZONE) METOLAZONE (INNOGENIX) APPROVAL= AP YEAR= 2021
NDA 214799 (pdf not found) INN (METOLAZONE) METOLAZONE (UNICHEM) APPROVAL= AP YEAR= 2021
NDA 215184 (pdf not found) INN (METOLAZONE) METOLAZONE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2021
NDA 215616 (pdf not found) INN (METOLAZONE) METOLAZONE (RENATA) APPROVAL= AP YEAR= 2022
NDA 216216 (pdf not found) INN (METOLAZONE) METOLAZONE (NE RX PHARMA) APPROVAL= AP YEAR= 2022
NDA 218606 (pdf not found) INN (METOLAZONE) METOLAZONE (LEADING) APPROVAL= AP YEAR= 2024
NDA 217563 (pdf not found) INN (METOLAZONE) METOLAZONE (MICRO LABS) APPROVAL= AP YEAR= 2024
NDA 017386 (pdf not found) INN (METOLAZONE) ZAROXOLYN (I3 PHARMS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 018535 (pdf not found) INN (METOLAZONE) DIULO (GD SEARLE LLC) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 019532 (pdf not found) INN (METOLAZONE) MYKROX (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 075543 (pdf not found) INN (METOLAZONE) METOLAZONE (ANI PHARMS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076466 (pdf not found) INN (METOLAZONE) METOLAZONE (SANDOZ) APPROVAL= AP YEAR= 2003
NDA 076698 (pdf not found) INN (METOLAZONE) METOLAZONE (MYLAN) APPROVAL= AP YEAR= 2003
NDA 076732 (pdf not found) INN (METOLAZONE) METOLAZONE (SANDOZ) APPROVAL= AP YEAR= 2003
NDA 076482 (pdf not found) INN (METOLAZONE) METOLAZONE (ROXANE) APPROVAL= AP YEAR= 2004
NDA 076600 (pdf not found) INN (METOLAZONE) METOLAZONE (TEVA) APPROVAL= AP YEAR= 2004 DISCONTINUED OBSOLETE
NDA 076833 (pdf not found) INN (METOLAZONE) METOLAZONE (TEVA) APPROVAL= AP YEAR= 2004 DISCONTINUED OBSOLETE
NDA 076891 (pdf not found) INN (METOLAZONE) METOLAZONE (WATSON LABS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 213251 (pdf not found) INN (METOLAZONE) METOLAZONE (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 213827 (pdf not found) INN (METOLAZONE) METOLAZONE (INNOGENIX) APPROVAL= AP YEAR= 2021
NDA 214799 (pdf not found) INN (METOLAZONE) METOLAZONE (UNICHEM) APPROVAL= AP YEAR= 2021
NDA 215184 (pdf not found) INN (METOLAZONE) METOLAZONE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2021
NDA 215616 (pdf not found) INN (METOLAZONE) METOLAZONE (RENATA) APPROVAL= AP YEAR= 2022
NDA 216216 (pdf not found) INN (METOLAZONE) METOLAZONE (NE RX PHARMA) APPROVAL= AP YEAR= 2022
NDA 218606 (pdf not found) INN (METOLAZONE) METOLAZONE (LEADING) APPROVAL= AP YEAR= 2024
NDA 217563 (pdf not found) INN (METOLAZONE) METOLAZONE (MICRO LABS) APPROVAL= AP YEAR= 2024