e-Drug3D

40

cas 113-42-8

CLASS

VARIOUS
OXYTOCIC
ERGOT ALKALOID
THE PREVENTION AND CONTROL OF POSTPARTUM HEMORRHAGE
ALPHA-1 ADRENERGIC RECEPTOR PARTIAL AGONIST
SEROTONERGIC (5-HT2) RECEPTOR PARTIAL AGONIST
CONSTRICTION OF UTERINE VASCULAR SMOOTH MUSCLE (PMID24328019)

ROUTE (list)

ORAL INJECTION

PK parameters

F 60 PERCENT
Tmax 1.12 HOUR
VD 56.1 LITER
Cl 14.4 LITER / HOUR
t1/2 3.39 HOUR

TARGET ALPHA-1 ADRENERGIC RECEPTOR
SEROTONERGIC (5-HT2) RECEPTOR

PDB
6DRY (STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR)

Ligand code = H8D (link to the list of PDB complexes)

Download experimental 3D coordinates of H8D with added hydrogens

MW 339.43
NB_atoms 25
XLogP 1.92
PSA 67.407
NB_HD 3
NB_HA 5
fsp3 0.45
Lipinski(0=no;1=yes) 1

FDA
NDA 006035 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHERGINE (EDISON THERAPS LLC) APPROVAL= AP YEAR= 1946 DISCONTINUED
NDA 090193 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHYLERGONOVINE MALEATE (AM REGENT) APPROVAL= AP YEAR= 2008
NDA 040889 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHYLERGONOVINE MALEATE (BRECKENRIDGE) APPROVAL= AP YEAR= 2010
NDA 091577 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHYLERGONOVINE MALEATE (CHARTWELL RX) APPROVAL= AP YEAR= 2011
NDA 210424 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHYLERGONOVINE MALEATE (GRANULES) APPROVAL= AP YEAR= 2018
NDA 211483 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHYLERGONOVINE MALEATE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2018
NDA 211455 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHYLERGONOVINE MALEATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2019
NDA 212233 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHYLERGONOVINE MALEATE (TRUPHARMA) APPROVAL= AP YEAR= 2020
NDA 211919 (pdf not found) INN (METHYLERGONOVINE MALEATE) METHYLERGONOVINE MALEATE (RISING) APPROVAL= AP YEAR= 2021