e-Drug3D

398

cas 175591-23-8

CLASS

NERVOUS SYSTEM
OPIOID ANALGESIC
NOREPINEPHRINE REUPTAKE INHIBITOR
MU OPIOD RECEPTOR AGONIST

ROUTE (list)

ORAL

PK parameters

F 32 PERCENT
Tmax 1.25 HOUR
VD 540 LITER
Cl 91.8 LITER / HOUR
PPB 20 PERCENT
t1/2 4 HOUR

MW 221.33
NB_atoms 16
XLogP 3.08
PSA 26.726
NB_HD 1
NB_HA 2
fsp3 0.57
Lipinski(0=no;1=yes) 1

FDA
NDA 022304 (pdf not found) INN (TAPENTADOL HYDROCHLORIDE) NUCYNTA (COLLEGIUM PHARM INC) APPROVAL= AP YEAR= 2008 NEWMOLECULARENTITY
NDA 200533 (pdf not found) INN (TAPENTADOL HYDROCHLORIDE) NUCYNTA ER (COLLEGIUM PHARM INC) APPROVAL= AP YEAR= 2011
NDA 203794 (pdf not found) INN (TAPENTADOL HYDROCHLORIDE) NUCYNTA (COLLEGIUM PHARM INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 204971 (pdf not found) INN (TAPENTADOL) TAPENTADOL (ACTAVIS ELIZABETH) APPROVAL= TA YEAR= 2015
NDA 205057 (pdf not found) INN (TAPENTADOL) TAPENTADOL (ROXANE) APPROVAL= TA YEAR= 2015
NDA 205015 (pdf not found) INN (TAPENTADOL) TAPENTADOL (ALKEM LABS LTD) APPROVAL= TA YEAR= 2016
NDA 206657 (pdf not found) INN (TAPENTADOL HYDROCHLORIDE) TAPENTADOL HYDROCHLORIDE (ACTAVIS LABS UT INC) APPROVAL= TA YEAR= 2016
NDA 204972 (pdf not found) INN (TAPENTADOL) TAPENTADOL (ACTAVIS ELIZABETH) APPROVAL= TA YEAR= 2017
NDA 206418 (pdf not found) INN (TAPENTADOL) TAPENTADOL (WEST-WARD PHARMS INT) APPROVAL= TA YEAR= 2017
NDA 209369 (pdf not found) INN (TAPENTADOL HYDROCHLORIDE) TAPENTADOL HYDROCHLORIDE (RHODES PHARMS) APPROVAL= TA YEAR= 2017
NDA 214378 (pdf not found) INN (TAPENTADOL HYDROCHLORIDE) TAPENTADOL HYDROCHLORIDE (HUMANWELL PHARMACEUTICAL US INC) APPROVAL= TA YEAR= 2022