e-Drug3D

396

FLOXURIDINE

INN
FLOXURIDINE

(has an active metabolite)

cas 50-91-9

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
INTERFERE WITH THE SYNTHESIS OF DNA AND RNA
RAPIDLY CATABOLIZED TO 5-FLUOROURACIL

ROUTE (list)

INJECTION

ATC code

L01BC09

PK parameters

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET URIDINE 5-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE)

PDB
2QCF (CRYSTAL STRUCTURE OF THE OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASE DOMAIN (ASP312ASN MUTANT) OF HUMAN UMP SYNTHASE BOUND TO 5-FLUORO-UMP)

Ligand code = 5FU (link to the list of PDB complexes)

Download experimental 3D coordinates of 5FU with added hydrogens

DrugCentral

Thymidylate synthase UNIPROT P04818 TYMS

Download SDF file

5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Formula:
C9H11FN2O5

Calculated chemical properties:

MW 246.20
NB_atoms 17
XLogP -1.68
PSA 102.866
NB_HD 3
NB_HA 7
fsp3 0.56
Lipinski(0=no;1=yes) 1

FDA
NDA 071055 (pdf not found) INN (FLOXURIDINE) FLOXURIDINE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016929 (pdf not found) INN (FLOXURIDINE) FUDR (HOSPIRA) APPROVAL= AP YEAR= 1970 DISCONTINUED
NDA 075387 (pdf not found) INN (FLOXURIDINE) FLOXURIDINE (HIKMA) APPROVAL= AP YEAR= 2000
NDA 075837 (pdf not found) INN (FLOXURIDINE) FLOXURIDINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2001
NDA 203008 (pdf not found) INN (FLOXURIDINE) FLOXURIDINE (AM REGENT) APPROVAL= AP YEAR= 2017 DISCONTINUED