e-Drug3D

395

cas 302-79-4

CLASS

DERMATOLOGICALS
KERATOLYTIC
ANTINEOPLASTIC AGENTS
RETINOIC ACID RECEPTOR (RAR) AGONIST
TREATMENT OF ACNE
ENDOGENOUS RETINOID METABOLITE OF VITAMIN A
INDUCES DIFFERENTIATION AND INHIBITS PROLIFERATION
INDUCES ITS OWN METABOLISM

ROUTE (list)

TOPICAL ORAL

PK parameters

Tmax 1.5 HOUR
PPB 95 PERCENT
t1/2 1.25 HOUR

TARGET RETINOIC ACID RECEPTOR (RAR)
CRABP I
CRABP II

PDB
3CWK (CRYSTAL STRUCTURE OF THE R132K:Y134F:R111L:T54V:L121E MUTANT OF CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AT 1.57 ANGSTROMS RESOLUTION)

Ligand code = REA_3CWK (link to the list of PDB complexes)

Download experimental 3D coordinates of REA_3CWK with added hydrogens

MW 299.42
NB_atoms 22
XLogP 4.27
PSA 32.802
NB_HD 0
NB_HA 2
fsp3 0.45
Lipinski(0=no;1=yes) 1

FDA
NDA 016921 (pdf not found) INN (TRETINOIN) RETIN-A (VALEANT INTL) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 017340 (pdf not found) INN (TRETINOIN) RETIN-A (VALEANT PHARMS NORTH) APPROVAL= AP YEAR= 1973
NDA 017522 (pdf not found) INN (TRETINOIN) RETIN-A (VALEANT BERMUDA) APPROVAL= AP YEAR= 1974
NDA 017579 (pdf not found) INN (TRETINOIN) RETIN-A (VALEANT INTL) APPROVAL= AP YEAR= 1975
NDA 017955 (pdf not found) INN (TRETINOIN) RETIN-A (BAUSCH) APPROVAL= AP YEAR= 1978
NDA 019049 (pdf not found) INN (TRETINOIN) RETIN-A (BAUSCH) APPROVAL= AP YEAR= 1988
NDA 019963 (pdf not found) INN (TRETINOIN) RENOVA (VALEANT PHARMS NORTH) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020438 (pdf not found) INN (TRETINOIN) VESANOID (CHEPLAPHARM) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020404 (pdf not found) INN (TRETINOIN) AVITA (MYLAN PHARMS INC) APPROVAL= AP YEAR= 1997
NDA 020475 (pdf not found) INN (TRETINOIN) RETIN-A MICRO (BAUSCH) APPROVAL= AP YEAR= 1997
NDA 020400 (pdf not found) INN (TRETINOIN) AVITA (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074873 (pdf not found) INN (TRETINOIN) TRETINOIN (TEVA PHARMS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075213 (pdf not found) INN (TRETINOIN) TRETINOIN (PADAGIS US) APPROVAL= AP YEAR= 1998
NDA 075264 (pdf not found) INN (TRETINOIN) TRETINOIN (PADAGIS US) APPROVAL= AP YEAR= 1998
NDA 075265 (pdf not found) INN (TRETINOIN) TRETINOIN (PADAGIS US) APPROVAL= AP YEAR= 1998
NDA 020922 (pdf not found) INN (MEQUINOL ; TRETINOIN) SOLAGE (ALMIRALL) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075260 (pdf not found) INN (TRETINOIN) TRETINOIN (WOCKHARDT) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021108 (pdf not found) INN (TRETINOIN) RENOVA (VALEANT PHARMS NORTH) APPROVAL= AP YEAR= 2000
NDA 075529 (pdf not found) INN (TRETINOIN) TRETINOIN (PADAGIS US) APPROVAL= AP YEAR= 2000
NDA 021112 (pdf not found) INN (FLUOCINOLONE ACETONIDE ; HYDROQUINONE ; TRETINOIN) TRI-LUMA (GALDERMA LABS LP) APPROVAL= AP YEAR= 2002
NDA 075589 (pdf not found) INN (TRETINOIN) TRETINOIN (PADAGIS US) APPROVAL= AP YEAR= 2002
NDA 076498 (pdf not found) INN (TRETINOIN) TRETINOIN (ZO SKIN HEALTH) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 050802 (pdf not found) INN (CLINDAMYCIN PHOSPHATE ; TRETINOIN) ZIANA (BAUSCH) APPROVAL= AP YEAR= 2006
NDA 022070 (pdf not found) INN (TRETINOIN) ATRALIN (DOW PHARM) APPROVAL= AP YEAR= 2007
NDA 077684 (pdf not found) INN (TRETINOIN) TRETINOIN (BARR LABS INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 090098 (pdf not found) INN (TRETINOIN) TRETINOIN (ALLERGAN) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 050803 (pdf not found) INN (CLINDAMYCIN PHOSPHATE ; TRETINOIN) VELTIN (ALMIRALL) APPROVAL= AP YEAR= 2010
NDA 201687 (pdf not found) INN (TRETINOIN) TRETINOIN (PH HEALTH) APPROVAL= AP YEAR= 2012
NDA 202209 (pdf not found) INN (TRETINOIN) TRETINOIN (ALLERGAN) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202026 (pdf not found) INN (TRETINOIN) TRETINOIN (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202567 (pdf not found) INN (TRETINOIN) TRETINOIN (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202564 (pdf not found) INN (CLINDAMYCIN PHOSPHATE ; TRETINOIN) CLINDAMYCIN PHOSPHATE AND TRETINOIN (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 2015
NDA 207955 (pdf not found) INN (TRETINOIN) TRETINOIN (MYLAN) APPROVAL= AP YEAR= 2015
NDA 208279 (pdf not found) INN (TRETINOIN) TRETINOIN (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2016
NDA 209353 (pdf not found) INN (TRETINOIN) ALTRENO (DOW PHARM) APPROVAL= AP YEAR= 2018
NDA 211644 (pdf not found) INN (TRETINOIN) TRETINOIN (TARO) APPROVAL= AP YEAR= 2019
NDA 211645 (pdf not found) INN (TRETINOIN) TRETINOIN (TARO) APPROVAL= AP YEAR= 2019
NDA 214902 (pdf not found) INN (BENZOYL PEROXIDE ; TRETINOIN) TWYNEO (MAYNE PHARMA) APPROVAL= AP YEAR= 2021
NDA 212845 (pdf not found) INN (CLINDAMYCIN PHOSPHATE ; TRETINOIN) CLINDAMYCIN PHOSPHATE AND TRETINOIN (SOLARIS PHARMA CORP) APPROVAL= AP YEAR= 2022
NDA 215713 (pdf not found) INN (TRETINOIN) TRETINOIN (TARO) APPROVAL= AP YEAR= 2023
NDA 215609 (pdf not found) INN (TRETINOIN) TRETINOIN MICROSPHERE (ENCUBE) APPROVAL= AP YEAR= 2023
NDA 216943 (pdf not found) INN (CLINDAMYCIN PHOSPHATE ; TRETINOIN) CLINDAMYCIN PHOSPHATE AND TRETINOIN (ENCUBE) APPROVAL= AP YEAR= 2023
NDA 217804 (pdf not found) INN (TRETINOIN) TRETINOIN (ALEMBIC) APPROVAL= AP YEAR= 2024
NDA 218561 (pdf not found) INN (TRETINOIN) TRETINOIN (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2024
NDA 217587 (pdf not found) INN (TRETINOIN) TRETINOIN (ENCUBE) APPROVAL= AP YEAR= 2025
NDA 217588 (pdf not found) INN (TRETINOIN) TRETINOIN (ENCUBE) APPROVAL= AP YEAR= 2025
NDA 217831 (pdf not found) INN (TRETINOIN) TRETINOIN (ENCUBE) APPROVAL= AP YEAR= 2025
NDA 218245 (pdf not found) INN (TRETINOIN) TRETINOIN (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2025
NDA 218246 (pdf not found) INN (TRETINOIN) TRETINOIN (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2025
NDA 218399 (pdf not found) INN (TRETINOIN) TRETINOIN (ALEMBIC) APPROVAL= AP YEAR= 2025