e-Drug3D
394
cas 59-92-7
CLASS
NERVOUS SYSTEM
ANTIPARKINSONIAN
ANTIDYSKINETICS
METABOLIC PRECURSOR OF DOPAMINE
ROUTE (list)
ORAL ENTERAL INHALATION
PK parameters
F 44 PERCENT
Tmax 0.5 HOUR
VD 110.5 LITER (65 KILOGRAM)
Cl 89.7 LITER / HOUR (65 KILOGRAM)
PPB 20 PERCENT
t1/2 1.7 HOUR
Solubility
SLIGHTLY SOLUBLE IN WATER
TARGET DOPA DECARBOXYLASE (DDC)
PDB
3TEH (CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS PHENYLALANYL-TRNA SYNTHETASE COMPLEXED WITH L-DOPA)
Ligand code = DAH (link to the list of PDB complexes)
Download experimental 3D coordinates of DAH with added hydrogens
D(1A) dopamine receptor UNIPROT P21728 DRD1
D(2) dopamine receptor UNIPROT P14416 DRD2
Formula:
C9H11NO4
Calculated chemical properties:
MW 196.18
NB_atoms 14
XLogP -1.28
PSA 101.019
NB_HD 4
NB_HA 5
fsp3 0.22
Lipinski(0=no;1=yes) 1
NB_atoms 14
XLogP -1.28
PSA 101.019
NB_HD 4
NB_HA 5
fsp3 0.22
Lipinski(0=no;1=yes) 1
FDA
NDA 016948 (pdf not found) INN (LEVODOPA) BENDOPA (VALEANT PHARM INTL) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073381 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073382 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073383 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016912 (pdf not found) INN (LEVODOPA) LARODOPA (ROCHE) APPROVAL= AP YEAR= 1970 DISCONTINUED
NDA 016913 (pdf not found) INN (LEVODOPA) DOPAR (SHIRE) APPROVAL= AP YEAR= 1970 DISCONTINUED
NDA 017555 (pdf not found) INN (CARBIDOPA ; LEVODOPA) SINEMET (ORGANON) APPROVAL= AP YEAR= 1975
NDA 019856 (pdf not found) INN (CARBIDOPA ; LEVODOPA) SINEMET CR (ORGANON LLC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073589 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 073607 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 073618 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 074260 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1993
NDA 074080 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 073586 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073587 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ANI PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073620 (pdf not found) INN (LEVODOPA) CARBIDOPA AND LEVODOPA (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1995 DISCONTINUED OBSOLETE
NDA 075091 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (MYLAN) APPROVAL= AP YEAR= 1999
NDA 021485 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) STALEVO 50 (ORION PHARMA) APPROVAL= AP YEAR= 2003
NDA 076212 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (APOTEX) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076521 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IMPAX LABS) APPROVAL= AP YEAR= 2004
NDA 076663 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (KV PHARM) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076699 (pdf not found) INN (CARBIDOPA ; LEVODOPA) PARCOPA (UCB INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076643 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBILEV (RANBAXY) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077828 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM INDS) APPROVAL= AP YEAR= 2007
NDA 077120 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (APOTEX INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078893 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RISING) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078536 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM INDS) APPROVAL= AP YEAR= 2008
NDA 078690 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM) APPROVAL= AP YEAR= 2009
NDA 090324 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (PHARMOBEDIENT) APPROVAL= AP YEAR= 2009
NDA 090631 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IMPAX LABS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 079085 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (SUN PHARM) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090786 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (WOCKHARDT LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090833 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (WOCKHARDT LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202323 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013
NDA 203312 (pdf not found) INN (CARBIDOPA ; LEVODOPA) RYTARY (IMPAX) APPROVAL= AP YEAR= 2015
NDA 203952 (pdf not found) INN (CARBIDOPA ; LEVODOPA) DUOPA (ABBVIE) APPROVAL= AP YEAR= 2015
NDA 209184 (pdf not found) INN (LEVODOPA) INBRIJA (MERZ) APPROVAL= AP YEAR= 2018
NDA 210341 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 203424 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214092 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 214091 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 214869 (pdf not found) INN (CARBIDOPA ; LEVODOPA) DHIVY (AVION PHARMS) APPROVAL= AP YEAR= 2021
NDA 213212 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (RISING) APPROVAL= AP YEAR= 2022
NDA 216505 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RUBICON RESEARCH) APPROVAL= AP YEAR= 2022
NDA 216537 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 208895 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA; LEVODOPA (SANDOZ INC) APPROVAL= TA YEAR= 2023
NDA 215999 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 217482 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RUBICON RESEARCH) APPROVAL= AP YEAR= 2024
NDA 217186 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CREXONT (IMPAX) APPROVAL= AP YEAR= 2024
NDA 210911 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA; LEODOPA (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2025
NDA 214495 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025
NDA 218939 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2025
NDA 219231 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2025
NDA 016948 (pdf not found) INN (LEVODOPA) BENDOPA (VALEANT PHARM INTL) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073381 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073382 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073383 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016912 (pdf not found) INN (LEVODOPA) LARODOPA (ROCHE) APPROVAL= AP YEAR= 1970 DISCONTINUED
NDA 016913 (pdf not found) INN (LEVODOPA) DOPAR (SHIRE) APPROVAL= AP YEAR= 1970 DISCONTINUED
NDA 017555 (pdf not found) INN (CARBIDOPA ; LEVODOPA) SINEMET (ORGANON) APPROVAL= AP YEAR= 1975
NDA 019856 (pdf not found) INN (CARBIDOPA ; LEVODOPA) SINEMET CR (ORGANON LLC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073589 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 073607 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 073618 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 074260 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1993
NDA 074080 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 073586 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073587 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ANI PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073620 (pdf not found) INN (LEVODOPA) CARBIDOPA AND LEVODOPA (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1995 DISCONTINUED OBSOLETE
NDA 075091 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (MYLAN) APPROVAL= AP YEAR= 1999
NDA 021485 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) STALEVO 50 (ORION PHARMA) APPROVAL= AP YEAR= 2003
NDA 076212 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (APOTEX) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076521 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IMPAX LABS) APPROVAL= AP YEAR= 2004
NDA 076663 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (KV PHARM) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076699 (pdf not found) INN (CARBIDOPA ; LEVODOPA) PARCOPA (UCB INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076643 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBILEV (RANBAXY) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077828 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM INDS) APPROVAL= AP YEAR= 2007
NDA 077120 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (APOTEX INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078893 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RISING) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078536 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM INDS) APPROVAL= AP YEAR= 2008
NDA 078690 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SUN PHARM) APPROVAL= AP YEAR= 2009
NDA 090324 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (PHARMOBEDIENT) APPROVAL= AP YEAR= 2009
NDA 090631 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (IMPAX LABS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 079085 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (SUN PHARM) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090786 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (WOCKHARDT LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090833 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (WOCKHARDT LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202323 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013
NDA 203312 (pdf not found) INN (CARBIDOPA ; LEVODOPA) RYTARY (IMPAX) APPROVAL= AP YEAR= 2015
NDA 203952 (pdf not found) INN (CARBIDOPA ; LEVODOPA) DUOPA (ABBVIE) APPROVAL= AP YEAR= 2015
NDA 209184 (pdf not found) INN (LEVODOPA) INBRIJA (MERZ) APPROVAL= AP YEAR= 2018
NDA 210341 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 203424 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214092 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 214091 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 214869 (pdf not found) INN (CARBIDOPA ; LEVODOPA) DHIVY (AVION PHARMS) APPROVAL= AP YEAR= 2021
NDA 213212 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (RISING) APPROVAL= AP YEAR= 2022
NDA 216505 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RUBICON RESEARCH) APPROVAL= AP YEAR= 2022
NDA 216537 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 208895 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA; LEVODOPA (SANDOZ INC) APPROVAL= TA YEAR= 2023
NDA 215999 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 217482 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (RUBICON RESEARCH) APPROVAL= AP YEAR= 2024
NDA 217186 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CREXONT (IMPAX) APPROVAL= AP YEAR= 2024
NDA 210911 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA; LEODOPA (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2025
NDA 214495 (pdf not found) INN (CARBIDOPA ; ENTACAPONE ; LEVODOPA) CARBIDOPA, LEVODOPA AND ENTACAPONE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025
NDA 218939 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2025
NDA 219231 (pdf not found) INN (CARBIDOPA ; LEVODOPA) CARBIDOPA AND LEVODOPA (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2025