e-Drug3D

389

cas 33643-46-8

CLASS

NERVOUS SYSTEM
ANESTHETIC
ANALGESICS
N-METHYL-D-ASPARTATE (NMDA) RECEPTORS ANTAGONIST
ANTIDEPRESSANT

ROUTE (list)

INJECTION NASAL

PK parameters

VD 188 LITER (65 KILOGRAM)
Cl 74 LITER / HOUR (65 KILOGRAM)
PPB 53 PERCENT
t1/2 2.8 HOUR

TARGET GLUTAMATE [NMDA] RECEPTOR
AMPA RECEPTOR

PDB
7SAC (S-(+)-KETAMINE BOUND GLUN1A-GLUN2B NMDA RECEPTORS AT 3.69 ANGSTROM RESOLUTION)

Ligand code = JC9 (link to the list of PDB complexes)

Download experimental 3D coordinates of JC9 with added hydrogens

MW 237.72
NB_atoms 16
XLogP 2.90
PSA 27.135
NB_HD 1
NB_HA 2
fsp3 0.46
Lipinski(0=no;1=yes) 1

FDA
NDA 071949 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HCL (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071950 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HCL (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071951 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HCL (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016812 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETALAR (PAR STERILE PRODUCTS) APPROVAL= AP YEAR= 1970 NEWMOLECULARENTITY
NDA 074524 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HYDROCHLORIDE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1996
NDA 074549 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1996
NDA 076092 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HYDROCHLORIDE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2001
NDA 211243 (pdf not found) INN (ESKETAMINE HYDROCHLORIDE) SPRAVATO (JANSSEN PHARMS) APPROVAL= AP YEAR= 2019
NDA 215808 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2023
NDA 216809 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HYDROCHLORIDE (GLAND PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 217858 (pdf not found) INN (KETAMINE HYDROCHLORIDE) KETAMINE HYDROCHLORIDE (PHARMATHER) APPROVAL= AP YEAR= 2025