e-Drug3D

387

cas 147-94-4

CLASS

ANTINEOPLASTIC

ANTIMETABOLITES

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

Tmax 1 HOUR
VD 7.1 LITER
Cl 0.13 LITER / HOUR
t1/2 40.4 HOUR

TARGET CYTIDINE KINASE

PDB
1P5Z (STRUCTURE OF HUMAN DCK COMPLEXED WITH CYTARABINE AND ADP-MG)

Ligand code = AR3 (link to the list of PDB complexes)

Download experimental 3D coordinates of AR3 with added hydrogens

MW 243.22
NB_atoms 17
XLogP -2.56
PSA 127.008
NB_HD 5
NB_HA 8
fsp3 0.56
Lipinski(0=no;1=yes) 1

FDA
NDA 071248 (pdf not found) INN (CYTARABINE) CYTARABINE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071249 (pdf not found) INN (CYTARABINE) CYTARABINE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016793 (label) INN (CYTARABINE) CYTARABINE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1969 DISCONTINUED
NDA 071471 (pdf not found) INN (CYTARABINE) CYTARABINE (HIKMA) APPROVAL= AP YEAR= 1989
NDA 071472 (pdf not found) INN (CYTARABINE) CYTARABINE (HIKMA) APPROVAL= AP YEAR= 1989
NDA 071868 (label) INN (CYTARABINE) CYTARABINE (HOSPIRA) APPROVAL= AP YEAR= 1990
NDA 072168 (pdf not found) INN (CYTARABINE) CYTARABINE (HOSPIRA) APPROVAL= AP YEAR= 1990
NDA 072945 (pdf not found) INN (CYTARABINE) CYTARABINE (HOSPIRA) APPROVAL= AP YEAR= 1994
NDA 074245 (pdf not found) INN (CYTARABINE) CYTARABINE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1994
NDA 075206 (pdf not found) INN (CYTARABINE) CYTOSAR-U (TEVA PHARMS USA) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 021041 (label) INN (CYTARABINE) DEPOCYT (PACIRA PHARMS INC) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075383 (pdf not found) INN (CYTARABINE) CYTARABINE (HOSPIRA) APPROVAL= AP YEAR= 1999
NDA 076512 (pdf not found) INN (CYTARABINE) CYTARABINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2004
NDA 200914 (pdf not found) INN (CYTARABINE) CYTARABINE (RISING) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200915 (pdf not found) INN (CYTARABINE) CYTARABINE (RISING) APPROVAL= AP YEAR= 2011
NDA 200916 (pdf not found) INN (CYTARABINE) CYTARABINE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 201784 (pdf not found) INN (CYTARABINE) CYTARABINE (RISING) APPROVAL= AP YEAR= 2012
NDA 209401 (label) INN (CYTARABINE ; DAUNORUBICIN) VYXEOS (JAZZ PHARMS THERAP) APPROVAL= AP YEAR= 2017
NDA 206190 (pdf not found) INN (CYTARABINE) CYTARABINE (MEITHEAL) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 205696 (pdf not found) INN (CYTARABINE) CYTARABINE (MEITHEAL) APPROVAL= AP YEAR= 2018
NDA 211937 (pdf not found) INN (CYTARABINE) CYTARABINE (GLAND) APPROVAL= AP YEAR= 2019
NDA 211938 (pdf not found) INN (CYTARABINE) CYTARABINE (GLAND) APPROVAL= AP YEAR= 2019
NDA 206189 (pdf not found) INN (CYTARABINE) CYTARABINE (MEITHEAL) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 208485 (pdf not found) INN (CYTARABINE) CYTARABINE (MEITHEAL) APPROVAL= AP YEAR= 2022