e-Drug3D
385
PROCARBAZINE
INN
PROCARBAZINE
cas 671-16-9
CLASS
ANTINEOPLASTIC
TREATMENT OF STAGE III AND IV HODGKIN'S DISEASE
MAY INHIBIT TRANSMETHYLATION OF METHYL GROUPS OF METHIONINE INTO T-RNA
HYDROGEN PEROXIDE FORMED DURING THE AUTO-OXIDATION OF THE DRUG MAY ATTACK PROTEIN SULFHYDRYL GROUPS CONTAINED IN RESIDUAL PROTEIN WHICH IS TIGHTLY BOUND TO DNA
ROUTE (list)
ORAL
ATC code
L01XB01
PK parameters
F 100 PERCENT
Tmax 1 HOUR
t1/2 0.16 HOUR
Solubility
SOLUBLE BUT UNSTABLE IN WATER
TARGET DNA
Unknown
Formula:
C12H19N3O
Calculated chemical properties:
MW 221.30
NB_atoms 16
XLogP 1.05
PSA 56.797
NB_HD 3
NB_HA 4
fsp3 0.42
Lipinski(0=no;1=yes) 1
NB_atoms 16
XLogP 1.05
PSA 56.797
NB_HD 3
NB_HA 4
fsp3 0.42
Lipinski(0=no;1=yes) 1
FDA
NDA 016785 (pdf not found) INN (PROCARBAZINE HYDROCHLORIDE) MATULANE (LEADIANT BIOSCI INC) APPROVAL= AP YEAR= 1969
NDA 016785 (pdf not found) INN (PROCARBAZINE HYDROCHLORIDE) MATULANE (LEADIANT BIOSCI INC) APPROVAL= AP YEAR= 1969