e-Drug3D

382

CYCLOTHIAZIDE

DISCONTINUED

INN
CYCLOTHIAZIDE

cas 134077-76-2

CLASS

CARDIOVASCULAR
DIURETIC
ANTIHYPERTENSIVE
POSITIVE ALLOSTERIC MODULATORS OF AMPA-TYPE GLUTAMATE RECEPTORS
POTENTIATOR

ROUTE (list)

ORAL

ATC code

C03AA09
C03AB09

PK parameters

Target

TARGET GLUTAMATE RECEPTOR 2

PDB
5WEO (ACTIVATED GLUA2 COMPLEX BOUND TO GLUTAMATE, CYCLOTHIAZIDE, AND STZ IN DIGITONIN)

Ligand code = CYZ (link to the list of PDB complexes)

Download experimental 3D coordinates of CYZ with added hydrogens

DrugCentral

Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3

Download SDF file

3-(6-bicyclo[2.2.1]hept-2-enyl)-6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

Formula:
C14H16ClN3O4S2

Calculated chemical properties:

MW 389.89
NB_atoms 24
XLogP 1.23
PSA 118.096
NB_HD 4
NB_HA 7
fsp3 0.43
Lipinski(0=no;1=yes) 1

FDA
NDA 013157 (pdf not found) INN (CYCLOTHIAZIDE) ANHYDRON (LILLY) APPROVAL= AP YEAR= 1963 NEWMOLECULARENTITY DISCONTINUED
NDA 018173 (pdf not found) INN (CYCLOTHIAZIDE) FLUIDIL (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1982 DISCONTINUED