e-Drug3D

377

cas 298-46-4

CLASS

NERVOUS SYSTEM
ANTICONVULSANT
ANALGESIC
ANTIMANIC AGENTS
SPECIFIC ANALGESIC FOR TRIGEMINAL NEURALGIA
CARBAMAZEPINE INDUCES ITS OWN METABOLISM
MECHANISM OF ACTION UNKNOWN (NUMEROUS PHARMACOLOGICAL EFFECTS HAVE BEEN DESCRIBED MODULATION OF ION CHANNELS (SODIUM AND CALCIUM), RECEPTOR-MEDIATED NEUROTRANSMISSION (GABAERGIC, GLUTAMATERGIC, AND MONOAMINERGIC), AND INTRACELLULAR SIGNALING PATHWAYS)

ROUTE (list)

ORAL INTRAVENOUS

PK parameters

F 89 PERCENT
Tmax 19 HOUR
VD 74.7 LITER (65 KILOGRAM)
Cl 4.8 LITER / HOUR
PPB 76 PERCENT
t1/2 37.5 HOUR

TARGET VOLTAGE-GATED SODIUM CHANNELS

PDB
6TFB (CARBAMAZEPINE BINDS FRIZZLED8)

Ligand code = N6W (link to the list of PDB complexes)

Download experimental 3D coordinates of N6W with added hydrogens

MW 236.27
NB_atoms 18
XLogP 3.39
PSA 40.207
NB_HD 2
NB_HA 3
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 070300 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070429 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016608 (label) INN (CARBAMAZEPINE) TEGRETOL (NOVARTIS) APPROVAL= AP YEAR= 1968
NDA 018281 (label) INN (CARBAMAZEPINE) TEGRETOL (NOVARTIS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 070231 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (INWOOD LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070541 (pdf not found) INN (CARBAMAZEPINE) EPITOL (TEVA) APPROVAL= AP YEAR= 1986
NDA 018927 (label) INN (CARBAMAZEPINE) TEGRETOL (NOVARTIS) APPROVAL= AP YEAR= 1987
NDA 071479 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (PLIVA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071696 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071940 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (JUBILANT CADISTA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 073524 (pdf not found) INN (CARBAMAZEPINE) EPITOL (TEVA) APPROVAL= AP YEAR= 1992
NDA 020234 (label) INN (CARBAMAZEPINE) TEGRETOL-XR (NOVARTIS) APPROVAL= AP YEAR= 1996
NDA 074649 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TARO) APPROVAL= AP YEAR= 1996
NDA 020712 (label) INN (CARBAMAZEPINE) CARBATROL (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 1997
NDA 075687 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TARO PHARM INDS) APPROVAL= AP YEAR= 2000
NDA 075875 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TARO) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075712 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TORRENT PHARMS) APPROVAL= AP YEAR= 2001
NDA 075714 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (CHARTWELL RX) APPROVAL= AP YEAR= 2002
NDA 075948 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (APOTEX) APPROVAL= AP YEAR= 2002
NDA 076525 (pdf not found) INN (CARBAMAZEPINE) TERIL (TARO) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021710 (label) INN (CARBAMAZEPINE) EQUETRO (VALIDUS PHARMS) APPROVAL= AP YEAR= 2004
NDA 076729 (pdf not found) INN (CARBAMAZEPINE) TERIL (TARO) APPROVAL= AP YEAR= 2004
NDA 077272 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TORRENT PHARMS) APPROVAL= AP YEAR= 2005
NDA 078115 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TARO) APPROVAL= AP YEAR= 2009
NDA 076697 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (ANI PHARMS) APPROVAL= AP YEAR= 2011
NDA 078986 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (APOTEX INC) APPROVAL= AP YEAR= 2011
NDA 078592 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TEVA PHARMS) APPROVAL= AP YEAR= 2012
NDA 078746 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TEVA PHARMS USA) APPROVAL= TA YEAR= 2012
NDA 201106 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TARO) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 206030 (label) INN (CARBAMAZEPINE) CARNEXIV (LUNDBECK PHARMS LLC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 205571 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2019
NDA 207798 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (UMEDICA) APPROVAL= AP YEAR= 2020
NDA 211623 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (UNIQUE PHARM) APPROVAL= AP YEAR= 2020
NDA 213311 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (CSPC OUYI) APPROVAL= AP YEAR= 2021
NDA 212948 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (ANBISON LAB) APPROVAL= AP YEAR= 2021
NDA 214328 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (RK PHARMA) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 215591 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (ZHEJIANG JIUZHOU) APPROVAL= AP YEAR= 2022
NDA 213284 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (UNICHEM) APPROVAL= AP YEAR= 2022
NDA 214277 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2022
NDA 216404 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (NOVAST LABS) APPROVAL= AP YEAR= 2022
NDA 216594 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (UMEDICA) APPROVAL= AP YEAR= 2022
NDA 216193 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 216235 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (SCIECURE PHARMA INC) APPROVAL= AP YEAR= 2023
NDA 212704 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 213159 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (APOTEX) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 218221 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (BIONPHARMA) APPROVAL= AP YEAR= 2024
NDA 215664 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (OSMOTICA PHARM US) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 212524 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (TORRENT) APPROVAL= AP YEAR= 2025
NDA 216623 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (ALEMBIC) APPROVAL= AP YEAR= 2025
NDA 217277 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2025
NDA 219072 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (YICHANG HUMANWELL) APPROVAL= AP YEAR= 2025
NDA 219939 (pdf not found) INN (CARBAMAZEPINE) CARBAMAZEPINE (ALEMBIC) APPROVAL= AP YEAR= 2025