e-Drug3D

372

cas 446-86-6

CLASS

ANTINEOPLASTIC
IMMUNOSUPPRESSIVE ANTIMETABOLITES
ANTIRHEUMATIC AGENTS
AZATHIOPRINE IS METABOLIZED TO 6-MERCAPTOPURINE (6-MP) AND THEN BY HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) AND DIVERSES KINASES WHICH LEAD TO THE INCORPORATION OF 6-THIOGUANINE NUCLEOTIDES (6-TGN) INTO DNA

ROUTE (list)

ORAL INJECTION

PK parameters

Tmax 1.5 HOUR
PPB 30 PERCENT

MW 277.29
NB_atoms 19
XLogP 0
PSA 103.414
NB_HD 1
NB_HA 8
fsp3 0.11
Lipinski(0=no;1=yes) 1

FDA
NDA 071056 (pdf not found) INN (AZATHIOPRINE SODIUM) AZATHIOPRINE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016324 (pdf not found) INN (AZATHIOPRINE) IMURAN (LEGACY PHARMA) APPROVAL= AP YEAR= 1968 NEWMOLECULARENTITY
NDA 017391 (pdf not found) INN (AZATHIOPRINE SODIUM) IMURAN (CASPER PHARMA LLC) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 074419 (pdf not found) INN (AZATHIOPRINE SODIUM) AZATHIOPRINE SODIUM (HIKMA) APPROVAL= AP YEAR= 1995
NDA 074069 (pdf not found) INN (AZATHIOPRINE) AZATHIOPRINE (AMNEAL) APPROVAL= AP YEAR= 1996
NDA 075252 (pdf not found) INN (AZATHIOPRINE) AZASAN (AAIPHARMA LLC) APPROVAL= AP YEAR= 1999
NDA 075568 (pdf not found) INN (AZATHIOPRINE) AZATHIOPRINE (RISING) APPROVAL= AP YEAR= 1999
NDA 077621 (pdf not found) INN (AZATHIOPRINE) AZATHIOPRINE (ZYDUS PHARMS USA) APPROVAL= AP YEAR= 2007
NDA 208687 (pdf not found) INN (AZATHIOPRINE) AZATHIOPRINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2020