e-Drug3D

371

ETHAMBUTOL

INN
ETHAMBUTOL

cas 74-55-5

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
TUBERCULOSTATIC
ANTIFUNGAL
ANTIBIOTIC
INHIBITS THE BIOSYNTHESIS OF CELL WALL ARABINOGALACTAN (AG) RESULTING IN ACCUMULATION OF MYCOLIC ACIDS AND CELL DEATH (PMID25547657)

ROUTE (list)

ORAL

ATC code

J04AK02
J04AM03
J04AM07
J04AM06

PK parameters

Tmax 3 HOUR
VD 110.5 LITER (65 KILOGRAM)
Cl 39 LITER / HOUR (65 KILOGRAM)
PPB 82 PERCENT
t1/2 3.1 HOUR

Target

TARGET ARABINOSYLTRANSFERASES (PMID19596878)

PDB
5NR3 (HUMAN DNMT3B PWWP DOMAIN IN COMPLEX WITH ETHAMBUTOL)

Ligand code = 95E (link to the list of PDB complexes)

Download experimental 3D coordinates of 95E with added hydrogens

DrugCentral

Probable arabinosyltransferase A UNIPROT P9WNL9 embA

Download SDF file

2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol

Formula:
C10H24N2O2

Calculated chemical properties:

MW 204.31
NB_atoms 14
XLogP -0.29
PSA 66.128
NB_HD 4
NB_HA 4
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 016320 (label) INN (ETHAMBUTOL HYDROCHLORIDE) MYAMBUTOL (KANCHAN HLTHCARE) APPROVAL= AP YEAR= 1967
NDA 075095 (pdf not found) INN (ETHAMBUTOL HYDROCHLORIDE) ETHAMBUTOL HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1999
NDA 076057 (pdf not found) INN (ETHAMBUTOL HYDROCHLORIDE) ETHAMBUTOL HYDROCHLORIDE (BARR) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 078939 (pdf not found) INN (ETHAMBUTOL HYDROCHLORIDE) ETHAMBUTOL HYDROCHLORIDE (LUPIN) APPROVAL= AP YEAR= 2009