e-Drug3D

369

cas 54-31-9

CLASS

CARDIOVASCULAR
DIURETIC
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) BLOCKER (PMID24117047)
NA+, K+, 2CL- CO-TRANSPORTER ISOFORM 1 (NKCC1) BLOCKER (PMID24117047)

ROUTE (list)

ORAL INJECTION SUBCUTANEOUS

PK parameters

F 60 PERCENT
Tmax 1.5 HOUR
VD 7.8 LITER (65 KILOGRAM)
Cl 6.2 LITER / HOUR (65 KILOGRAM)
PPB 95 PERCENT
t1/2 2 HOUR

TARGET NKCC1
CFTR

PDB
3RF4 (ANCYLOSTOMA CEYLANICUM MIF IN COMPLEX WITH FUROSEMIDE)

Ligand code = FUN (link to the list of PDB complexes)

Download experimental 3D coordinates of FUN with added hydrogens

MW 329.74
NB_atoms 21
XLogP 0.56
PSA 111.705
NB_HD 3
NB_HA 7
fsp3 0.08
Lipinski(0=no;1=yes) 1

FDA
NDA 018419 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018420 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018507 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018670 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WYETH AYERST) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018868 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (KALAPHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 019036 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070014 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (ASTRAZENECA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070019 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070023 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SMITH AND NEPHEW) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070078 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SMITH AND NEPHEW) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070095 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (IGI LABS INC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070096 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (IGI LABS INC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070604 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 074017 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (MARSAM PHARMS LLC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016273 (label) INN (FUROSEMIDE) LASIX (VALIDUS PHARMS) APPROVAL= AP YEAR= 1966
NDA 016363 (pdf not found) INN (FUROSEMIDE) LASIX (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 017688 (pdf not found) INN (FUROSEMIDE) LASIX (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 018025 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (INTL MEDICATION) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 018267 (label) INN (FUROSEMIDE) FUROSEMIDE (HIKMA) APPROVAL= AP YEAR= 1981
NDA 018487 (label) INN (FUROSEMIDE) FUROSEMIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018569 (label) INN (FUROSEMIDE) FUROSEMIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1981
NDA 018369 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018415 (label) INN (FUROSEMIDE) FUROSEMIDE (ESJAY PHARMA) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018667 (label) INN (FUROSEMIDE) FUROSEMIDE (HOSPIRA) APPROVAL= AP YEAR= 1982
NDA 018413 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 018579 (label) INN (FUROSEMIDE) FUROSEMIDE (AM REGENT) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 018790 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 018823 (label) INN (FUROSEMIDE) FUROSEMIDE (HIKMA) APPROVAL= AP YEAR= 1983
NDA 018753 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (INTL MEDICATION) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 018902 (label) INN (FUROSEMIDE) FUROSEMIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1984
NDA 070043 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070086 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (HIKMA) APPROVAL= AP YEAR= 1985
NDA 070449 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070450 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WATSON LABS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070017 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 1986
NDA 070082 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070412 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070413 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (ANI PHARMS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070528 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070433 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (HIKMA) APPROVAL= AP YEAR= 1987
NDA 070434 (label) INN (FUROSEMIDE) FUROSEMIDE (HIKMA) APPROVAL= AP YEAR= 1987
NDA 070578 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070655 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (PHARMOBEDIENT CNSLTG) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071379 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (ANI PHARMS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 018750 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 070100 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071594 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (ANI PHARMS) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 018370 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SUPERPHARM) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 071439 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (HIKMA) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 072080 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (HOSPIRA) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 074337 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (HOSPIRA) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 075241 (label) INN (FUROSEMIDE) FUROSEMIDE (HOSPIRA) APPROVAL= AP YEAR= 1999
NDA 076796 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (PRINSTON INC) APPROVAL= AP YEAR= 2004
NDA 077293 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (LEADING) APPROVAL= AP YEAR= 2005
NDA 078010 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (IPCA LABS LTD) APPROVAL= AP YEAR= 2006
NDA 077941 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 2007
NDA 091258 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202747 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2014
NDA 203428 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2014
NDA 207552 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2016
NDA 212174 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2019
NDA 213902 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (GLAND) APPROVAL= AP YEAR= 2020
NDA 208435 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (AREVA PHARMS) APPROVAL= AP YEAR= 2020
NDA 214766 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SAGENT) APPROVAL= AP YEAR= 2021
NDA 212803 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (MEITHEAL) APPROVAL= AP YEAR= 2022
NDA 209988 (label) INN (FUROSEMIDE) FUROSCIX (SCPHARMACEUTICALS) APPROVAL= AP YEAR= 2022
NDA 216629 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (GRAVITI PHARMS) APPROVAL= AP YEAR= 2022
NDA 216860 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 215856 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (SABA ILAC SANAYIVE) APPROVAL= AP YEAR= 2024
NDA 217294 (pdf not found) INN (FUROSEMIDE) LASIX ONYU (SQ INNOVATION, INC) APPROVAL= TA YEAR= 2024
NDA 217557 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (ASPIRO) APPROVAL= AP YEAR= 2024
NDA 218831 (pdf not found) INN (FUROSEMIDE) FUROSEMIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2025