e-Drug3D

365

cas 359-83-1

CLASS

NERVOUS SYSTEM
ANALGESICS, OPIOID WITH AGONIST/ANTAGONIST ACTION
NARCOTIC ANTAGONISTS
(+)-PENTAZOCINE IS A SELECTIVE SIGMA-1 RECEPTOR (SIG-1R) AGONIST (PMID25065832)

ROUTE (list)

INJECTION ORAL

PK parameters

Tmax 1.7 HOUR
VD 221 LITER (65 KILOGRAM)
Cl 89.7 LITER / HOUR (65 KILOGRAM)
PPB 61 PERCENT
t1/2 3.6 HOUR

TARGET SIGMA OPIOID RECEPTOR

PDB
6DK1 (HUMAN SIGMA-1 RECEPTOR BOUND TO (+)-PENTAZOCINE)

Ligand code = GM4 (link to the list of PDB complexes)

Download experimental 3D coordinates of GM4 with added hydrogens

MW 285.42
NB_atoms 21
XLogP 3.88
PSA 26.82
NB_HD 1
NB_HA 2
fsp3 0.58
Lipinski(0=no;1=yes) 1

FDA
NDA 016194 (label) INN (PENTAZOCINE LACTATE) TALWIN (HOSPIRA) APPROVAL= AP YEAR= 1967 DISCONTINUED
NDA 016732 (pdf not found) INN (PENTAZOCINE HYDROCHLORIDE) TALWIN 50 (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1969 DISCONTINUED
NDA 016891 (pdf not found) INN (ASPIRIN ; PENTAZOCINE HYDROCHLORIDE) TALWIN COMPOUND (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 018458 (label) INN (ACETAMINOPHEN ; PENTAZOCINE HYDROCHLORIDE) TALACEN (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018733 (label) INN (NALOXONE HYDROCHLORIDE ; PENTAZOCINE HYDROCHLORIDE) TALWIN NX (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 074736 (pdf not found) INN (NALOXONE HYDROCHLORIDE ; PENTAZOCINE HYDROCHLORIDE) NALOXONE HYDROCHLORIDE AND PENTAZOCINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1997
NDA 074699 (pdf not found) INN (ACETAMINOPHEN ; PENTAZOCINE HYDROCHLORIDE) ACETAMINOPHEN AND PENTAZOCINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075523 (pdf not found) INN (NALOXONE HYDROCHLORIDE ; PENTAZOCINE HYDROCHLORIDE) NALOXONE HYDROCHLORIDE AND PENTAZOCINE HYDROCHLORIDE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2000
NDA 075735 (pdf not found) INN (NALOXONE HYDROCHLORIDE ; PENTAZOCINE HYDROCHLORIDE) NALOXONE HYDROCHLORIDE AND PENTAZOCINE HYDROCHLORIDE (LUPIN) APPROVAL= AP YEAR= 2001
NDA 076202 (pdf not found) INN (ACETAMINOPHEN ; PENTAZOCINE HYDROCHLORIDE) ACETAMINOPHEN AND PENTAZOCINE HYDROCHLORIDE (GAVIS PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED