e-Drug3D

364

CLOMIPHENE

INN
CLOMIPHENE

cas 911-45-5

CLASS

GENITO
INITIATION OF OVULATION
FERTILITY AGENTS, FEMALE
ESTROGEN RECEPTOR ANTAGONIST
ZUCLOMIPHENE (CIS) HAS A LONGER HALF-LIFE THAN ENCLOMIPHENE (TRANS)

ROUTE (list)

ORAL

ATC code

G03GB02

PK parameters

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET ESTROGEN RECEPTOR

DrugCentral

Estrogen receptor UNIPROT P03372 ESR1

Download SDF file

2-[4-[(Z)-2-chloro-1,2-di(phenyl)ethenyl]phenoxy]-N,N-diethylethanamine

Formula:
C26H28ClNO

Calculated chemical properties:

MW 405.94
NB_atoms 29
XLogP 6.56
PSA 16.165
NB_HD 0
NB_HA 2
fsp3 0.23
Lipinski(0=no;1=yes) 0

FDA
NDA 016131 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMID (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1967 DISCONTINUED
NDA 018361 (pdf not found) INN (CLOMIPHENE CITRATE) SEROPHENE (EMD SERONO) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 072196 (pdf not found) INN (CLOMIPHENE CITRATE) MILOPHENE (GRANATA BIO) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 075528 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (COSETTE) APPROVAL= AP YEAR= 1999
NDA 216545 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (RUBICON) APPROVAL= AP YEAR= 2024
NDA 216739 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (APPCO) APPROVAL= AP YEAR= 2024