e-Drug3D

363

TESTOLACTONE

DISCONTINUED

INN
TESTOLACTONE

cas 968-93-4

CLASS

ANTINEOPLASTIC
INHIBITION OF STEROID AROMATASE ACTIVITY AND CONSEQUENT REDUCTION IN ESTRONE SYNTHESIS FROM ADRENAL ANDROSTENEDIONE
TREATMENT OF BREAST CANCER IN POSTMENOPAUSAL WOMEN

ROUTE (list)

ORAL INJECTION

ATC code

PK parameters

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET CYTOCHROME P450 19 (AROMATASE)

DrugCentral

Aromatase UNIPROT P11511 CYP19A1

Download SDF file

(4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,10b,11,12-octahydro-3H-naphtho[6,5-f]chromene-2,8-dione

Formula:
C19H24O3

Calculated chemical properties:

MW 300.38
NB_atoms 22
XLogP 3.59
PSA 45.635
NB_HD 0
NB_HA 3
fsp3 0.68
Lipinski(0=no;1=yes) 1

FDA
NDA 016119 (pdf not found) INN (TESTOLACTONE) TESLAC (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1969 NEWMOLECULARENTITY DISCONTINUED
NDA 016118 (pdf not found) INN (TESTOLACTONE) TESLAC (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1970 DISCONTINUED