e-Drug3D

36

cas 511-12-6

CLASS

NERVOUS SYSTEM
VASOCONSTRICTOR
ANTIMIGRAINE
ANALGESICS NON-NARCOTIC
5-HYDROXYTRYPTAMINE 1 RECEPTOR AGONISTS
SYMPATHOLYTICS

ROUTE (list)

INJECTION NASAL SUBCUTANEOUS

PK parameters

Tmax 0.38 HOUR
VD 800 LITER
Cl 90 LITER / HOUR
PPB 93 PERCENT
t1/2 9 HOUR

TARGET 5-HYDROXYTRYPTAMINE 1 RECEPTOR
5-HYDROXYTRYPTAMINE 2 RECEPTOR
ALPHA ADRENERGIC RECEPTOR
DOPAMINE RECEPTOR

PDB
4IAQ (CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH DIHYDROERGOTAMINE (PSI COMMUNITY TARGET))

Ligand code = 2GM (link to the list of PDB complexes)

Download experimental 3D coordinates of 2GM with added hydrogens

MW 583.68
NB_atoms 43
XLogP 2.08
PSA 112.357
NB_HD 3
NB_HA 10
fsp3 0.48
Lipinski(0=no;1=yes) 0

FDA
NDA 018885 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE ; HEPARIN SODIUM ; LIDOCAINE HYDROCHLORIDE) EMBOLEX (NOVARTIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 005929 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) D.H.E. 45 (BAUSCH) APPROVAL= AP YEAR= 1946 DISCONTINUED
NDA 020148 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) MIGRANAL (BAUSCH) APPROVAL= AP YEAR= 1997
NDA 040453 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (HIKMA) APPROVAL= AP YEAR= 2003
NDA 040475 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (PADAGIS US) APPROVAL= AP YEAR= 2003
NDA 206621 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (HIKMA PHARMS) APPROVAL= AP YEAR= 2017
NDA 207264 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 211393 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (HIKMA) APPROVAL= AP YEAR= 2020
NDA 212046 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (PROVEPHARM SAS) APPROVAL= AP YEAR= 2020
NDA 212907 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (CIPLA) APPROVAL= AP YEAR= 2020
NDA 213436 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) TRUDHESA (IMPEL PHARMS) APPROVAL= AP YEAR= 2021
NDA 214105 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (AMNEAL) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 216881 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2023
NDA 215623 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (GLAND) APPROVAL= AP YEAR= 2023
NDA 212334 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (CIPLA) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 215228 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (AGGREGA) APPROVAL= AP YEAR= 2025
NDA 215400 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) BREKIYA AUTOINJECTOR (AMNEAL) APPROVAL= AP YEAR= 2025
NDA 216747 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) DIHYDROERGOTAMINE MESYLATE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 217901 (pdf not found) INN (DIHYDROERGOTAMINE MESYLATE) ATZUMI (SATSUMA PHARMS) APPROVAL= AP YEAR= 2025