e-Drug3D

347

cas 60-32-2

CLASS

BLOOD
HEMOSTATIC
ANTIFIBRINOLYTIC AGENTS
COMPETITIVE INHIBITOR OF PLASMIN

ROUTE (list)

ORAL INJECTION

PK parameters

F 100 PERCENT
Tmax 1.2 HOUR
VD 23.1 LITER
Cl 10.1 LITER / HOUR
PPB 8 PERCENT
t1/2 2 HOUR

TARGET PLASMINOGEN

PDB
2ZM9 (STRUCTURE OF 6-AMINOHEXANOATE-DIMER HYDROLASE, A61V, S112A, A124V, R187S, F264C, G291R, G338A, D370Y MUTANT (HYB-S4M94) WITH SUBSTRATE)

Ligand code = ACA (link to the list of PDB complexes)

Download experimental 3D coordinates of ACA with added hydrogens

MW 130.17
NB_atoms 9
XLogP -0.74
PSA 60.653
NB_HD 2
NB_HA 3
fsp3 0.83
Lipinski(0=no;1=yes) 1

FDA
NDA 070694 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 015197 (pdf not found) INN (AMINOCAPROIC ACID) AMICAR (HIKMA) APPROVAL= AP YEAR= 1964 NEWMOLECULARENTITY
NDA 015229 (pdf not found) INN (AMINOCAPROIC ACID) AMICAR (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 015230 (pdf not found) INN (AMINOCAPROIC ACID) AMICAR (HIKMA) APPROVAL= AP YEAR= 1964
NDA 018590 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 070522 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (ABRAXIS PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070010 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID IN PLASTIC CONTAINER (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 071192 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (LUITPOLD) APPROVAL= AP YEAR= 1987
NDA 070888 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 074759 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075602 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC (HIKMA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 209060 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (SUNNY) APPROVAL= AP YEAR= 2018
NDA 212492 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 212780 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 212814 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (VISTAPHARM LLC) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 211629 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (ANI PHARMS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212494 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (TRUPHARMA) APPROVAL= AP YEAR= 2020
NDA 212938 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (MSN) APPROVAL= AP YEAR= 2020
NDA 212110 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (ADAPTIS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213825 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (AJENAT PHARMS) APPROVAL= AP YEAR= 2021
NDA 213928 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (CARNEGIE) APPROVAL= AP YEAR= 2021
NDA 214140 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (CARNEGIE) APPROVAL= AP YEAR= 2021
NDA 215510 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (FLORIDA) APPROVAL= AP YEAR= 2022
NDA 213944 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (APPCO) APPROVAL= AP YEAR= 2022
NDA 216464 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (ANNORA PHARMA) APPROVAL= AP YEAR= 2022
NDA 216804 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2022
NDA 214458 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (TARO) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 213213 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (SUNNY) APPROVAL= AP YEAR= 2023
NDA 215100 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (MSN) APPROVAL= AP YEAR= 2024
NDA 213216 (pdf not found) INN (AMINOCAPROIC ACID) AMINOCAPROIC ACID (APOZEAL PHARMS) APPROVAL= AP YEAR= 2025