e-Drug3D

341

cas 72-69-5

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANT
ADRENERGIC UPTAKE INHIBITORS
NOREPINEPHRINE-REUPTAKE INHIBITORS

ROUTE (list)

ORAL

PK parameters

Tmax 4 HOUR
VD 1430 LITER (65 KILOGRAM)
Cl 39 LITER / HOUR (65 KILOGRAM)
PPB 88 PERCENT
t1/2 30 HOUR

TARGET NORADRENALINE TRANSPORTER
SEROTONIN TRANSPORTER

PDB
4M48 (X-RAY STRUCTURE OF DOPAMINE TRANSPORTER ELUCIDATES ANTIDEPRESSANT MECHANISM)

Ligand code = 21B (link to the list of PDB complexes)

Download experimental 3D coordinates of 21B with added hydrogens

MW 263.37
NB_atoms 20
XLogP 3.83
PSA 14.685
NB_HD 1
NB_HA 1
fsp3 0.26
Lipinski(0=no;1=yes) 1

FDA
NDA 014684 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) AVENTYL HYDROCHLORIDE (LILLY) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 014685 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) AVENTYL (RANBAXY) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 018012 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) PAMELOR (SPECGX LLC) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 018013 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) PAMELOR (SPECGX LLC) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 073553 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (MAYNE PHARMA) APPROVAL= AP YEAR= 1992 OBSOLETE
NDA 073554 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (MAYNE PHARMA) APPROVAL= AP YEAR= 1992 OBSOLETE
NDA 073555 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (MAYNE PHARMA) APPROVAL= AP YEAR= 1992 OBSOLETE
NDA 073556 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1992
NDA 074054 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 074234 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074132 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1995
NDA 073667 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074835 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 075520 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 2000
NDA 075606 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (PHARM ASSOC) APPROVAL= AP YEAR= 2000
NDA 077965 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 213441 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 217731 (pdf not found) INN (NORTRIPTYLINE HYDROCHLORIDE) NORTRIPTYLINE HYDROCHLORIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2023