e-Drug3D

338

cas 6735-59-7

CLASS

VARIOUS
ANTIDOTES AGAINST ORGANOPHOSPHATE PESTICIDES
REACTIVATE CHOLINESTERASE WHICH HAS BEEN INACTIVATED BY PHOSPHORYLATION (ORGANOPHOSPHATES INACTIVATE ACETYLCHOLINESTERASE BY REACTING COVALENTLY WITH THE ACTIVE CENTER SERINE)

ROUTE (list)

ORAL INJECTION INTRAMUSCULAR

PK parameters

Tmax 0.26 HOUR
VD 107.2 LITER (65 KILOGRAM)
Cl 57.2 LITER / HOUR (65 KILOGRAM)
PPB 0 PERCENT
t1/2 3 HOUR

MW 137.16
NB_atoms 10
XLogP 0.32
PSA 33.854
NB_HD 1
NB_HA 2
fsp3 0.14
Lipinski(0=no;1=yes) 1

FDA
NDA 072224 (pdf not found) INN (PRALIDOXIME CHLORIDE) PRALIDOXIME CHLORIDE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 014122 (pdf not found) INN (PRALIDOXIME CHLORIDE) PROTOPAM CHLORIDE (WYETH AYERST) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 014134 (pdf not found) INN (PRALIDOXIME CHLORIDE) PROTOPAM CHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 1964 NEWMOLECULARENTITY
NDA 018799 (pdf not found) INN (PRALIDOXIME CHLORIDE) PRALIDOXIME CHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018986 (pdf not found) INN (PRALIDOXIME CHLORIDE) PRALIDOXIME CHLORIDE AUTOINJECTOR (MERIDIAN MEDCL TECHN) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 021175 (pdf not found) INN (ATROPINE ; PRALIDOXIME CHLORIDE) ATNAA (US ARMY) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021983 (pdf not found) INN (ATROPINE ; PRALIDOXIME CHLORIDE) DUODOTE (MMT) APPROVAL= AP YEAR= 2006