e-Drug3D

337

cas 57-22-7

CLASS

ANTINEOPLASTIC
ALKALOID FROM A COMMON FLOWERING HERB THE PERIWINKLE PLANT (VINCA ROSEA LINN)
TUBULIN MODULATORS
TREATMENT OF ACUTE LEUKEMIA
INHIBITION OF MICROTUBULE FORMATION IN MITOTIC SPINDLE, RESULTING IN AN ARREST OF DIVIDING CELLS AT THE METAPHASE STAGE

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

VD 156 LITER (65 KILOGRAM)
Cl 7.8 LITER / HOUR (65 KILOGRAM)
PPB 60 PERCENT
t1/2 87 HOUR

TARGET TUBULIN BETA CHAIN

PDB
7A69 (NANODISC RECONSTITUTED HUMAN ABCB1 IN COMPLEX WITH MRK16 FAB AND VINCRISTINE)

Ligand code = R1Q (link to the list of PDB complexes)

Download experimental 3D coordinates of R1Q with added hydrogens

MW 824.95
NB_atoms 60
XLogP 3.52
PSA 141.356
NB_HD 3
NB_HA 14
fsp3 0.57
Lipinski(0=no;1=yes) 0

FDA
NDA 070411 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070777 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070778 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070873 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071222 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071223 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071559 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (HOSPIRA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071560 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (HOSPIRA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071561 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (HOSPIRA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071937 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 014103 (pdf not found) INN (VINCRISTINE SULFATE) ONCOVIN (LILLY) APPROVAL= AP YEAR= 1963 DISCONTINUED
NDA 071426 (pdf not found) INN (VINCRISTINE SULFATE) VINCASAR PFS (TEVA PARENTERAL) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070867 (pdf not found) INN (VINCRISTINE SULFATE) VINCREX (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071484 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE PFS (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 075493 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE PFS (TEVA PHARMS USA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 076296 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076401 (pdf not found) INN (VINCRISTINE SULFATE) VINCRISTINE SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 202497 (pdf not found) INN (VINCRISTINE SULFATE) MARQIBO KIT (ACROTECH) APPROVAL= AP YEAR= 2012 DISCONTINUED