e-Drug3D

335

IDOXURIDINE

DISCONTINUED

INN
IDOXURIDINE

cas 54-42-2

CLASS

ANTIINFECTIVES
ANTIVIRAL AGENTS
NUCLEIC ACID SYNTHESIS INHIBITORS
INTERFER WITH DNA SYNTHESIS

ROUTE (list)

OPHTHALMIC

ATC code

D06BB01
J05AB02
S01AD01

PK parameters

Target

TARGET DNA

PDB
1KI7 (CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-IODODEOXYURIDINE)

Ligand code = ID2 (link to the list of PDB complexes)

Download experimental 3D coordinates of ID2 with added hydrogens

DrugCentral

Unknown

Download SDF file

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione

Formula:
C9H11IN2O5

Calculated chemical properties:

MW 354.10
NB_atoms 17
XLogP -1.22
PSA 102.545
NB_HD 3
NB_HA 7
fsp3 0.56
Lipinski(0=no;1=yes) 1

FDA
NDA 013935 (pdf not found) INN (IDOXURIDINE) HERPLEX (ALLERGAN) APPROVAL= AP YEAR= 1963 DISCONTINUED
NDA 014169 (pdf not found) INN (IDOXURIDINE) DENDRID (ALCON) APPROVAL= AP YEAR= 1963 DISCONTINUED
NDA 013934 (pdf not found) INN (IDOXURIDINE) STOXIL (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 015868 (pdf not found) INN (IDOXURIDINE) STOXIL (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1967 DISCONTINUED