e-Drug3D

333

cas 50-47-5

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANT
ADRENERGIC REUPTAKE INHIBITORS
NOREPINEPHRINE REUPTAKE INHIBITORS

ROUTE (list)

ORAL

PK parameters

VD 975 LITER (65 KILOGRAM)
Cl 42.9 LITER / HOUR (65 KILOGRAM)
PPB 84 PERCENT
t1/2 22 HOUR

TARGET NORADRENALINE TRANSPORTER
SEROTONIN TRANSPORTER

PDB
2QB4 (CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-LEUCINE, SODIUM AND DESIPRAMINE)

Ligand code = DSM (link to the list of PDB complexes)

Download experimental 3D coordinates of DSM with added hydrogens

MW 266.38
NB_atoms 20
XLogP 3.53
PSA 16.019
NB_HD 1
NB_HA 2
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 071864 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071865 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071866 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071867 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 014399 (label) INN (DESIPRAMINE HYDROCHLORIDE) NORPRAMIN (VALIDUS PHARMS) APPROVAL= AP YEAR= 1964
NDA 013621 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) PERTOFRANE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 071588 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 1987
NDA 071601 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 1987
NDA 071602 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 1987
NDA 071766 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 1987
NDA 071800 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ANI PHARMS INC) APPROVAL= AP YEAR= 1987 DISCONTINUED OBSOLETE
NDA 071801 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ANI PHARMS INC) APPROVAL= AP YEAR= 1987 DISCONTINUED OBSOLETE
NDA 071802 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ANI PHARMS INC) APPROVAL= AP YEAR= 1987 DISCONTINUED OBSOLETE
NDA 072099 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 072100 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 072101 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 072102 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 072103 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1988
NDA 072104 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 074430 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 1996
NDA 071803 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 071804 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ANI PHARMS INC) APPROVAL= AP YEAR= 1997 DISCONTINUED OBSOLETE
NDA 207433 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (HERITAGE) APPROVAL= AP YEAR= 2016
NDA 208105 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2016
NDA 205153 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 204963 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (NOVAST LABS) APPROVAL= AP YEAR= 2017
NDA 209785 (pdf not found) INN (DESIPRAMINE HYDROCHLORIDE) DESIPRAMINE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2021