e-Drug3D

33

cas 59-30-3

CLASS

BLOOD
VITAMIN B9
DIETARY SUPPLEMENT

ROUTE (list)

ORAL INJECTION INTRAVENOUS

PK parameters

-

PDB
4P3R (CRYOGENIC WT DHFR, TIME-AVERAGED ENSEMBLE)

Ligand code = FOL (link to the list of PDB complexes)

Download experimental 3D coordinates of FOL with added hydrogens

MW 439.40
NB_atoms 32
XLogP -2.71
PSA 197.673
NB_HD 5
NB_HA 13
fsp3 0.21
Lipinski(0=no;1=yes) 0

FDA
NDA 018933 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE ; VITAMIN A ; VITAMIN E) M.V.I.-12 LYOPHILIZED (TELIGENT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080903 (pdf not found) INN (FOLIC ACID) FOLIC ACID (VALEANT PHARM INTL) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083598 (pdf not found) INN (FOLIC ACID) FOLIC ACID (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086296 (pdf not found) INN (FOLIC ACID) FOLIC ACID (VINTAGE PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088949 (pdf not found) INN (FOLIC ACID) FOLIC ACID (PIONEER PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 006012 (pdf not found) INN (FERROUS SULFATE ; FOLIC ACID) FOLVRON (LEDERLE) APPROVAL= AP YEAR= 1946 DISCONTINUED
NDA 005897 (pdf not found) INN (FOLIC ACID) FOLVITE (WYETH PHARMS INC) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 006071 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN E) BEROCCA PN (ROCHE) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 006135 (pdf not found) INN (FOLIC ACID) FOLIC ACID (LILLY) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 008809 (pdf not found) INN (FOLIC ACID) M.V.I.-12 ADULT (HOSPIRA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 080680 (pdf not found) INN (FOLIC ACID) FOLIC ACID (WATSON LABS) APPROVAL= AP YEAR= 1971
NDA 080600 (pdf not found) INN (FOLIC ACID) FOLIC ACID (HIKMA PHARMS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080784 (pdf not found) INN (FOLIC ACID) FOLIC ACID (PUREPAC PHARM) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 083000 (pdf not found) INN (FOLIC ACID) FOLIC ACID (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080686 (pdf not found) INN (FOLIC ACID) FOLIC ACID (IMPAX LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080691 (pdf not found) INN (FOLIC ACID) FOLIC ACID (WHITEWORTH TOWN PLSN) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080755 (pdf not found) INN (FOLIC ACID) FOLIC ACID (EVERYLIFE) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083133 (pdf not found) INN (FOLIC ACID) FOLIC ACID (TABLICAPS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083141 (pdf not found) INN (FOLIC ACID) FOLIC ACID (WATSON LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083526 (pdf not found) INN (FOLIC ACID) FOLIC ACID (MK LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080816 (pdf not found) INN (FOLIC ACID) FOLIC ACID (LANNETT) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 084158 (pdf not found) INN (FOLIC ACID) FOLIC ACID (PHARMERAL) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 084472 (pdf not found) INN (FOLIC ACID) FOLIC ACID (SANDOZ) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084915 (pdf not found) INN (FOLIC ACID) FOLIC ACID (NEXGEN PHARMA INC) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085061 (pdf not found) INN (FOLIC ACID) FOLIC ACID (CONTRACT PHARMACAL) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085141 (pdf not found) INN (FOLIC ACID) FOLIC ACID (WATSON LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 018440 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.C. 9+3 (ABRAXIS PHARM) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 087438 (pdf not found) INN (FOLIC ACID) FOLICET (MISSION PHARMA) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018439 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) MVC PLUS (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087828 (pdf not found) INN (FOLIC ACID) FOLIC ACID (USL PHARMA) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018920 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PHYTONADIONE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I. PEDIATRIC (HOSPIRA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088199 (pdf not found) INN (FOLIC ACID) FOLIC ACID (UDL) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088730 (pdf not found) INN (FOLIC ACID) FOLIC ACID (VANGARD) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 089177 (pdf not found) INN (FOLIC ACID) FOLIC ACID (BARR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089202 (pdf not found) INN (FOLIC ACID) FOLIC ACID (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 020176 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PANTOTHENIC ACID ; PHYTONADIONE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; VITAMIN A PALMITATE ; VITAMIN E) VITAPED (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 081066 (pdf not found) INN (FOLIC ACID) FOLIC ACID (BEN VENUE) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 021163 (pdf not found) INN (ALPHA-TOCOPHEROL ACETATE ; ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN K) INFUVITE ADULT (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2000
NDA 021265 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) INFUVITE PEDIATRIC (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2001
NDA 021559 (pdf not found) INN (FOLIC ACID) INFUVITE ADULT (SANDOZ INC) APPROVAL= AP YEAR= 2003 OBSOLETE
NDA 021625 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E ; VITAMIN K) M.V.I. ADULT (HOSPIRA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021643 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E ; VITAMIN K) M.V.I. ADULT PHARMACY BULK PACKAGE (HOSPIRA) APPROVAL= AP YEAR= 2004 NEWAPPLICATION DISCONTINUED
NDA 021646 (pdf not found) INN (FOLIC ACID) INFUVITE PEDIATRIC PHARMACY BULK PACKAGE (SANDOZ INC) APPROVAL= AP YEAR= 2004 OBSOLETE
NDA 040514 (pdf not found) INN (FOLIC ACID) FOLIC ACID (JUBILANT CADISTA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 040582 (pdf not found) INN (FOLIC ACID) FOLIC ACID (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 040625 (pdf not found) INN (FOLIC ACID) FOLIC ACID (AMNEAL PHARM) APPROVAL= AP YEAR= 2005
NDA 040796 (pdf not found) INN (FOLIC ACID) FOLIC ACID (LEADING) APPROVAL= AP YEAR= 2009
NDA 090035 (pdf not found) INN (FOLIC ACID) FOLIC ACID (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2009
NDA 040756 (pdf not found) INN (FOLIC ACID) FOLIC ACID (PH HEALTH) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091145 (pdf not found) INN (FOLIC ACID) FOLIC ACID (AIPING PHARM INC) APPROVAL= AP YEAR= 2013
NDA 202437 (pdf not found) INN (FOLIC ACID) FOLIC ACID (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 204418 (pdf not found) INN (FOLIC ACID) FOLIC ACID (NUVO PHARMS INC) APPROVAL= AP YEAR= 2015
NDA 211064 (pdf not found) INN (FOLIC ACID) FOLIC ACID (ATHEM) APPROVAL= AP YEAR= 2019
NDA 202522 (pdf not found) INN (FOLIC ACID) FOLIC ACID (XGEN PHARMS) APPROVAL= AP YEAR= 2019