e-Drug3D

328

METHYLDOPA


INN
METHYLDOPA

(is an active metabolite)

cas 555-30-6
CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
L-ISOMER OF ALPHA-METHYLDOPA
DOPA DECARBOXYLASE INHIBITOR TO DEPLETE ANIMAL TISSUES OF NOREPINEPHRINE
SYMPATHOLYTICS
PROBABLY IS DUE TO ITS METABOLISM TO ALPHA-METHYL-NOREPINEPHRINE WHICH THEN LOWERS ARTERIAL PRESSURE

ROUTE (list)

ORAL

ATC code

C02AB01
C02LB01
C02AB02

PK parameters

VD 44.8 LITER (65 KILOGRAM)
Cl 13.6 LITER / HOUR (65 KILOGRAM)
PPB 15 PERCENT
t1/2 1.8 HOUR

Solubility

SOLUBLE IN WATER


Target

TARGET DOPA DECARBOXYLASE

DrugCentral

Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A

Download SDF file (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid

Formula:
C10H13NO4

Calculated chemical properties:

MW 210.21
NB_atoms 15
XLogP -0.89
PSA 100.044
NB_HD 4
NB_HA 5
fsp3 0.30
Lipinski(0=no;1=yes) 1

FDA
NDA 070192 (pdf not found) INN (METHYLDOPA) METHYLDOPA (ROXANE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070193 (pdf not found) INN (METHYLDOPA) METHYLDOPA (ROXANE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070194 (pdf not found) INN (METHYLDOPA) METHYLDOPA (ROXANE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070245 (pdf not found) INN (METHYLDOPA) METHYLDOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070246 (pdf not found) INN (METHYLDOPA) METHYLDOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070247 (pdf not found) INN (METHYLDOPA) METHYLDOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070260 (pdf not found) INN (METHYLDOPA) METHYLDOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070261 (pdf not found) INN (METHYLDOPA) METHYLDOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070262 (pdf not found) INN (METHYLDOPA) METHYLDOPA (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070331 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070365 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070366 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070367 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070368 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070452 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070654 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND CHLOROTHIAZIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070669 (pdf not found) INN (METHYLDOPA) METHYLDOPA (SUPERPHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070670 (pdf not found) INN (METHYLDOPA) METHYLDOPA (SUPERPHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070688 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070689 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070749 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070750 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070783 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND CHLOROTHIAZIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070829 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (SANDOZ) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070830 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (SANDOZ) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070853 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070854 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071067 (pdf not found) INN (METHYLDOPA) METHYLDOPA (TEVA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071105 (pdf not found) INN (METHYLDOPA) METHYLDOPA (TEVA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071106 (pdf not found) INN (METHYLDOPA) METHYLDOPA (TEVA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071458 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071459 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071460 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071461 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071751 (pdf not found) INN (METHYLDOPA) METHYLDOPA (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071752 (pdf not found) INN (METHYLDOPA) METHYLDOPA (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071753 (pdf not found) INN (METHYLDOPA) METHYLDOPA (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071897 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071898 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071899 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071900 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071920 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071921 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071922 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071923 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 013400 (label) INN (METHYLDOPA) ALDOMET (MERCK) APPROVAL= AP YEAR= 1962 DISCONTINUED
NDA 013402 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) ALDORIL 15 (MERCK) APPROVAL= AP YEAR= 1962 DISCONTINUED
NDA 016016 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) ALDOCLOR-150 (MERCK) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 018389 (pdf not found) INN (METHYLDOPA) ALDOMET (MERCK) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018934 (pdf not found) INN (METHYLDOPA) METHYLDOPA (CHARTWELL RX) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 070070 (pdf not found) INN (METHYLDOPA) METHYLDOPA (ACCORD HLTHCARE) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070075 (pdf not found) INN (METHYLDOPA) METHYLDOPA (MYLAN) APPROVAL= AP YEAR= 1985
NDA 070076 (pdf not found) INN (METHYLDOPA) METHYLDOPA (RISING) APPROVAL= AP YEAR= 1985
NDA 070084 (pdf not found) INN (METHYLDOPA) METHYLDOPA (ACCORD HLTHCARE) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070085 (pdf not found) INN (METHYLDOPA) METHYLDOPA (ACCORD HLTHCARE) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070060 (pdf not found) INN (METHYLDOPA) METHYLDOPA (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070073 (pdf not found) INN (METHYLDOPA) METHYLDOPA (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070074 (pdf not found) INN (METHYLDOPA) METHYLDOPA (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070098 (pdf not found) INN (METHYLDOPA) METHYLDOPA (HERITAGE PHARMA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070182 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070183 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070264 (pdf not found) INN (METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (MYLAN) APPROVAL= AP YEAR= 1986 OBSOLETE
NDA 070265 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (RISING) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070332 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PARKE DAVIS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070333 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PARKE DAVIS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070343 (pdf not found) INN (METHYLDOPA) METHYLDOPA (HERITAGE PHARMA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070543 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070544 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070625 (pdf not found) INN (METHYLDOPA) METHYLDOPA (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070703 (pdf not found) INN (METHYLDOPA) METHYLDOPA (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071006 (pdf not found) INN (METHYLDOPA) METHYLDOPA (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071009 (pdf not found) INN (METHYLDOPA) METHYLDOPA (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070535 (pdf not found) INN (METHYLDOPA) METHYLDOPA (STRIDES PHARMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070536 (pdf not found) INN (METHYLDOPA) METHYLDOPA (STRIDES PHARMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070537 (pdf not found) INN (METHYLDOPA) METHYLDOPA (STRIDES PHARMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070612 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070613 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070614 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070616 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071700 (pdf not found) INN (METHYLDOPA) METHYLDOPA (CHARTWELL RX) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071819 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (TEVA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071820 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (TEVA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071821 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (TEVA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071822 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (TEVA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072126 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PLIVA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072127 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PLIVA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072128 (pdf not found) INN (METHYLDOPA) METHYLDOPA (PLIVA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 070958 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 070959 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 070960 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 071069 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072507 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (DAVA PHARMS INC) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072508 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (DAVA PHARMS INC) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072509 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (DAVA PHARMS INC) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072510 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND HYDROCHLOROTHIAZIDE (DAVA PHARMS INC) APPROVAL= AP YEAR= 1989 DISCONTINUED

Other links:

PubChem
ChemicalProbes

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VigiAccess
SIDER side effects

ChemSynthesis
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