e-Drug3D

327

ACETOHEXAMIDE

DISCONTINUED

INN
ACETOHEXAMIDE

(has an active metabolite)

cas 968-81-0

CLASS

METABOLISM
ANTIDIABETIC
HYPOGLYCEMIC AGENTS
SULFONYLUREAS

ROUTE (list)

ORAL

ATC code

A10BB31

PK parameters

Target

TARGET ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL

PDB
8J2O (CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN-COMPLEX WITH ACETOHEXAMIDE AT 2.6 A RESOLUTION)

Ligand code = TF9 (link to the list of PDB complexes)

Download experimental 3D coordinates of TF9 with added hydrogens

DrugCentral

Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8

Download SDF file

3-(4-acetylphenyl)sulfonyl-1-cyclohexylurea

Formula:
C15H20N2O4S

Calculated chemical properties:

MW 324.40
NB_atoms 22
XLogP 2.21
PSA 89.404
NB_HD 2
NB_HA 6
fsp3 0.47
Lipinski(0=no;1=yes) 1

FDA
NDA 070753 (pdf not found) INN (ACETOHEXAMIDE) ACETOHEXAMIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070754 (pdf not found) INN (ACETOHEXAMIDE) ACETOHEXAMIDE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 013378 (pdf not found) INN (ACETOHEXAMIDE) DYMELOR (LILLY) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 070869 (pdf not found) INN (ACETOHEXAMIDE) ACETOHEXAMIDE (ANI PHARMS INC) APPROVAL= AP YEAR= 1987 DISCONTINUED OBSOLETE
NDA 070870 (pdf not found) INN (ACETOHEXAMIDE) ACETOHEXAMIDE (ANI PHARMS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071893 (pdf not found) INN (ACETOHEXAMIDE) ACETOHEXAMIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071894 (pdf not found) INN (ACETOHEXAMIDE) ACETOHEXAMIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1987 DISCONTINUED