e-Drug3D

322

cas 396-01-0

CLASS

CARDIOVASCULAR
ANTIKALIURETIC

ROUTE (list)

ORAL

PK parameters

Tmax 1.1 HOUR
VD 845 LITER (65 KILOGRAM)
Cl 245.7 LITER / HOUR (65 KILOGRAM)
PPB 58 PERCENT
t1/2 4.3 HOUR

-

PDB
3JQ7 (CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 6-PHENYLPTERIDINE-2,4,7-TRIAMINE (DX2))

Ligand code = DX2 (link to the list of PDB complexes)

Download experimental 3D coordinates of DX2 with added hydrogens

MW 253.28
NB_atoms 19
XLogP 0.83
PSA 110.737
NB_HD 6
NB_HA 7
fsp3 0.00
Lipinski(0=no;1=yes) 0

FDA
NDA 071737 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (VITARINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071980 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072022 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 074857 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (NOVARTIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 013174 (pdf not found) INN (TRIAMTERENE) DYRENIUM (ADVANZ PHARMA) APPROVAL= AP YEAR= 1964 NEWMOLECULARENTITY
NDA 016042 (label) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) DYAZIDE (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 1965 DISCONTINUED
NDA 019129 (label) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) MAXZIDE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1984
NDA 071251 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (APOTEX INC) APPROVAL= AP YEAR= 1987
NDA 071851 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 071969 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072011 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (SANDOZ) APPROVAL= AP YEAR= 1988
NDA 073191 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073281 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (SANDOZ) APPROVAL= AP YEAR= 1992
NDA 073449 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1993
NDA 074259 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (ANI PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073467 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (ANI PHARMS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074026 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (PLIVA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074701 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (MYLAN) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074821 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (SANDOZ) APPROVAL= AP YEAR= 1997
NDA 074970 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (ANI PHARMS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075052 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 201407 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2011
NDA 208360 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 208358 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (CADILA) APPROVAL= AP YEAR= 2019
NDA 211581 (pdf not found) INN (TRIAMTERENE) TRIAMTERENE (AGNITIO) APPROVAL= AP YEAR= 2019
NDA 214768 (pdf not found) INN (TRIAMTERENE) TRIAMTERENE (BIOCON GENERICS) APPROVAL= AP YEAR= 2022
NDA 216211 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (RUBICON) APPROVAL= AP YEAR= 2022
NDA 214611 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TRIAMTERENE) TRIAMTERENE AND HYDROCHLOROTHIAZIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025 DISCONTINUED